000043552 001__ 43552
000043552 005__ 20240812100247.0
000043552 0247_ $$2doi$$a10.6083/bpxhc43552
000043552 037__ $$aIR
000043552 041__ $$aeng
000043552 245__ $$aSex differences in inflammation and brain function in methamphetamine use disorder
000043552 260__ $$bOregon Health and Science University
000043552 269__ $$a2024
000043552 336__ $$aAbstract
000043552 520__ $$aEffective treatments for methamphetamine (MA)-use disorder (MUD) are critically needed. Treatment outcomes, however, are variable, especially for women, as sex differences in treatment efficacy have not been adequately studied. With rates of MUD recently tripling in women, it's critical to identify sex-specific mechanisms and targets for tailored medications. Women exhibit higher levels of inflammation and greater activation in emotional centers of the brain. These differences may explain why women resort to MA more frequently to alleviate negative emotions. Despite evidence of sex differences in biological mechanisms, there is a lack of studies extending these results in MUD. This proposal therefore aims to address the knowledge gap in sex differences in MUD, focusing on inflammation and brain function.
000043552 540__ $$fCC BY
000043552 542__ $$fIn copyright - joint owners
000043552 650__ $$aMethamphetamine$$022135
000043552 650__ $$aTreatment Outcome$$029509
000043552 650__ $$aSex Characteristics$$025917
000043552 650__ $$aWomen$$027986
000043552 650__ $$aInterleukin-1beta$$037488
000043552 650__ $$aNeuroimaging$$039660
000043552 6531_ $$amethamphetamine-use disorder
000043552 6531_ $$ainflammation, brain
000043552 6531_ $$abrain function
000043552 6531_ $$alimbic connectivity
000043552 691__ $$aSchool of Medicine$$041369
000043552 692__ $$aDepartment of Psychiatry$$041443
000043552 7001_ $$aSonnon, Alea$$uOregon Health and Science University$$041354
000043552 7001_ $$aNagum, Jazryn$$uOregon Health and Science University$$041354
000043552 7001_ $$aDennis, Laura$$uOregon Health and Science University$$041354
000043552 7001_ $$aKohno, Milky$$uOregon Health and Science University$$041354
000043552 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043552 8564_ $$9696f22e8-4e69-47eb-888c-b8933078bfba$$s61116$$uhttps://digitalcollections.ohsu.edu/record/43552/files/ResearchWeek.2024.Sonnon.Alea.pdf
000043552 980__ $$aResearch Week