TY  - GEN
AB  - Ashwagandha (Withania somnifera, WS) is a botanical commonly used in Ayurvedic medicine and other traditional medicine systems. In recent years, WS has gained mainstream popularity as a botanical dietary supplement for its reputed adaptogenic effects, particularly for the relief of insomnia and stress. Withanolides, a class of steroidal lactones that are relatively unique to WS, are thought to be its main bioactive compounds and have been the focus of much research. There is limited data, however, regarding which withanolides are present in human plasma, and at what concentration, following ingestion of WS products. One significant challenge is the lack of good quality reference standards. To address this challenge, our research team is developing liquid chromatography-mass spectrometry (LC-MS) based methods in collaboration with OHSU’s Bioanalytical Shared Resource/Pharmacokinetics Core for analyzing withanolides in mouse and human plasma. These projects will generate critical data for our understanding of a widely used botanical, while also supporting future studies investigating (a) herb-drug interactions, (b) whether compounds and concentrations showing activity in preclinical models are relevant for efficacy in humans, and (c) the oral absorption of potentially bioactive non-withanolide compounds.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon State University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Speers, Alex
AU  - Lozano-Ortiz, Axel
AU  - Quinn, Joseph
AU  - Munar, Myrna
AU  - Marney, Luke
AU  - Choi, Jaewoo
AU  - Yang, Liping
AU  - Maier, Claudia
AU  - Soumyanath, Amala
DA  - 2024
DO  - 10.6083/bpxhc43557
DO  - doi
ID  - 43557
KW  - Sleep Initiation and Maintenance Disorders
KW  - Withania
KW  - Herb-Drug Interactions
KW  - Pharmacokinetics
KW  - ashwagandha
KW  - botanical dietary supplements
KW  - older adults
L1  - https://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
L2  - https://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
L4  - https://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
N2  - Ashwagandha (Withania somnifera, WS) is a botanical commonly used in Ayurvedic medicine and other traditional medicine systems. In recent years, WS has gained mainstream popularity as a botanical dietary supplement for its reputed adaptogenic effects, particularly for the relief of insomnia and stress. Withanolides, a class of steroidal lactones that are relatively unique to WS, are thought to be its main bioactive compounds and have been the focus of much research. There is limited data, however, regarding which withanolides are present in human plasma, and at what concentration, following ingestion of WS products. One significant challenge is the lack of good quality reference standards. To address this challenge, our research team is developing liquid chromatography-mass spectrometry (LC-MS) based methods in collaboration with OHSU’s Bioanalytical Shared Resource/Pharmacokinetics Core for analyzing withanolides in mouse and human plasma. These projects will generate critical data for our understanding of a widely used botanical, while also supporting future studies investigating (a) herb-drug interactions, (b) whether compounds and concentrations showing activity in preclinical models are relevant for efficacy in humans, and (c) the oral absorption of potentially bioactive non-withanolide compounds.
PB  - Oregon Health and Science University
PY  - 2024
T1  - Exploring human pharmacokinetics of withanolides, bioactive compounds from the botanical ashwagandha
TI  - Exploring human pharmacokinetics of withanolides, bioactive compounds from the botanical ashwagandha
UR  - https://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
Y1  - 2024
ER  -