000043557 001__ 43557
000043557 005__ 20240823153304.0
000043557 0247_ $$2doi$$a10.6083/bpxhc43557
000043557 037__ $$aIR
000043557 041__ $$aeng
000043557 245__ $$aExploring human pharmacokinetics of withanolides, bioactive compounds from the botanical ashwagandha
000043557 260__ $$bOregon Health and Science University
000043557 269__ $$a2024
000043557 336__ $$aAbstract
000043557 520__ $$aAshwagandha (Withania somnifera, WS) is a botanical commonly used in Ayurvedic medicine and other traditional medicine systems. In recent years, WS has gained mainstream popularity as a botanical dietary supplement for its reputed adaptogenic effects, particularly for the relief of insomnia and stress. Withanolides, a class of steroidal lactones that are relatively unique to WS, are thought to be its main bioactive compounds and have been the focus of much research. There is limited data, however, regarding which withanolides are present in human plasma, and at what concentration, following ingestion of WS products. One significant challenge is the lack of good quality reference standards. To address this challenge, our research team is developing liquid chromatography-mass spectrometry (LC-MS) based methods in collaboration with OHSU’s Bioanalytical Shared Resource/Pharmacokinetics Core for analyzing withanolides in mouse and human plasma. These projects will generate critical data for our understanding of a widely used botanical, while also supporting future studies investigating (a) herb-drug interactions, (b) whether compounds and concentrations showing activity in preclinical models are relevant for efficacy in humans, and (c) the oral absorption of potentially bioactive non-withanolide compounds.
000043557 540__ $$fCC BY
000043557 542__ $$fIn copyright - joint owners
000043557 650__ $$aSleep Initiation and Maintenance Disorders$$020863
000043557 650__ $$aWithania$$034332
000043557 650__ $$aHerb-Drug Interactions$$035123
000043557 650__ $$aPharmacokinetics$$023908
000043557 6531_ $$aashwagandha
000043557 6531_ $$abotanical dietary supplements
000043557 6531_ $$aolder adults
000043557 691__ $$aSchool of Medicine$$041369
000043557 692__ $$aDepartment of Neurology$$041431
000043557 7001_ $$aSpeers, Alex$$uOregon Health and Science University$$041354
000043557 7001_ $$aLozano-Ortiz, Axel$$uOregon Health and Science University$$041354
000043557 7001_ $$aQuinn, Joseph$$uOregon Health and Science University$$041354
000043557 7001_ $$aMunar, Myrna$$uOregon State University
000043557 7001_ $$aMarney, Luke$$uOregon Health and Science University$$041354
000043557 7001_ $$aChoi, Jaewoo$$uOregon Health and Science University$$041354
000043557 7001_ $$aYang, Liping$$uOregon Health and Science University$$041354
000043557 7001_ $$aMaier, Claudia$$uOregon Health and Science University$$041354
000043557 7001_ $$aSoumyanath, Amala$$uOregon Health and Science University$$041354
000043557 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043557 8564_ $$97aee03e0-63a6-4547-af06-429bd3d30c28$$s185681$$uhttps://digitalcollections.ohsu.edu/record/43557/files/ResearchWeek.2024.Speers.Alex.pdf
000043557 980__ $$aResearch Week