TY  - GEN
AB  - Pregnancy causes complex hormonal changes, leading to physiologic decreases of insulin sensitivity, onset of gestational diabetes (GDM), and worsening conditions associated with insulin resistance (IR). These factors, although not fully understood, are closely linked to the metabolic effects of elevated hormones during pregnancy. Studies suggest GDM can cause offspring to develop impaired glucose tolerance. Metformin reduces hepatic glucose production, increases hepatic insulin sensitivity, and combats GDM/IR conditions. It is unknown how metformin exposure during fetal development impacts glucose homeostasis in offspring.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Maior-Leichtfried, Anna
AU  - Blomenkamp, Hannah
AU  - Dean, Tyler
AU  - Kirigiti, Melissa
AU  - Sauter, Kristin
AU  - Kievit, Paul
DA  - 2024
DO  - 10.6083/bpxhc43562
DO  - doi
ID  - 43562
KW  - Insulin Resistance
KW  - Pregnancy
KW  - Glucose Tolerance Tests
KW  - Macaca mulatta
KW  - insulin sensitivity
KW  - glucose homeostasis
KW  - maternal diet
KW  - offspring development
KW  - metformin treatment
L1  - https://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
L2  - https://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
L4  - https://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
N2  - Pregnancy causes complex hormonal changes, leading to physiologic decreases of insulin sensitivity, onset of gestational diabetes (GDM), and worsening conditions associated with insulin resistance (IR). These factors, although not fully understood, are closely linked to the metabolic effects of elevated hormones during pregnancy. Studies suggest GDM can cause offspring to develop impaired glucose tolerance. Metformin reduces hepatic glucose production, increases hepatic insulin sensitivity, and combats GDM/IR conditions. It is unknown how metformin exposure during fetal development impacts glucose homeostasis in offspring.
PB  - Oregon Health and Science University
PY  - 2024
T1  - Effects of diet changes and maternal metformin consumption during pregnancy on both maternal and offspring insulin resistance
TI  - Effects of diet changes and maternal metformin consumption during pregnancy on both maternal and offspring insulin resistance
UR  - https://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
Y1  - 2024
ER  -