000043562 001__ 43562
000043562 005__ 20240823152522.0
000043562 0247_ $$2doi$$a10.6083/bpxhc43562
000043562 037__ $$aIR
000043562 041__ $$aeng
000043562 245__ $$aEffects of diet changes and maternal metformin consumption during pregnancy on both maternal and offspring insulin resistance
000043562 260__ $$bOregon Health and Science University
000043562 269__ $$a2024
000043562 336__ $$aAbstract
000043562 520__ $$aPregnancy causes complex hormonal changes, leading to physiologic decreases of insulin sensitivity, onset of gestational diabetes (GDM), and worsening conditions associated with insulin resistance (IR). These factors, although not fully understood, are closely linked to the metabolic effects of elevated hormones during pregnancy. Studies suggest GDM can cause offspring to develop impaired glucose tolerance. Metformin reduces hepatic glucose production, increases hepatic insulin sensitivity, and combats GDM/IR conditions. It is unknown how metformin exposure during fetal development impacts glucose homeostasis in offspring.
000043562 540__ $$fCC BY
000043562 542__ $$fIn copyright - joint owners
000043562 650__ $$aInsulin Resistance$$020877
000043562 650__ $$aPregnancy$$024523
000043562 650__ $$aGlucose Tolerance Tests$$019585
000043562 650__ $$aMacaca mulatta$$021724
000043562 6531_ $$ainsulin sensitivity
000043562 6531_ $$aglucose homeostasis
000043562 6531_ $$amaternal diet
000043562 6531_ $$aoffspring development
000043562 6531_ $$ametformin treatment
000043562 692__ $$aOregon National Primate Research Center$$041497
000043562 7001_ $$aMaior-Leichtfried, Anna$$uOregon Health and Science University$$041354
000043562 7001_ $$aBlomenkamp, Hannah$$uOregon Health and Science University$$041354
000043562 7001_ $$aDean, Tyler$$uOregon Health and Science University$$041354
000043562 7001_ $$aKirigiti, Melissa$$uOregon Health and Science University$$041354
000043562 7001_ $$aSauter, Kristin$$uOregon Health and Science University$$041354
000043562 7001_ $$aKievit, Paul$$uOregon Health and Science University$$041354
000043562 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043562 8564_ $$931a75e26-c069-4823-acc7-4f083c96cd32$$s68554$$uhttps://digitalcollections.ohsu.edu/record/43562/files/ResearchWeek.2024.MaiorLeichtfried.Anna.pdf
000043562 980__ $$aResearch Week