TY  - GEN
AB  - Recently, longitudinal changes in human gut microbiome composition have been proposed to be more robust markers of host health than cross-sectional variation. However, it is unclear how gut microbiome dynamics are influenced by chronic inflammatory conditions, such as inflammatory bowel disease (IBD), cancer, and obesity. Microbiome features, including species diversity and taxonomic composition, could be evaluated to assess the system’s capacity to resist (degree of change from baseline: resistance) and recover (ability to return to baseline: resilience) following a perturbation. By applying a perturbation to the gut environment, we can observe microbiome features at baseline and post-perturbation to assess both resistance and resilience. Although challenging to measure, resistance and resilience may be related to the health of the host. Given this, we aim to understand the utility of resistance and resilience as potential biomarkers of host health and treatment response in patients with chronic inflammation.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Turner, Christina
AU  - Gibbons, Sean
AU  - Mooney, Mike
AU  - Boudreau, Eilis
AU  - McWeeney, Shannon
DA  - 2024
DO  - 10.6083/bpxhc43576
DO  - doi
ID  - 43576
KW  - Gastrointestinal Microbiome
KW  - Microbiota
KW  - Inflammatory Bowel Diseases
KW  - Obesity
KW  - human gut microbiome
KW  - temporal dynamics
KW  - perturbations
KW  - chronic inflammation
L1  - https://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
L2  - https://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
L4  - https://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
N2  - Recently, longitudinal changes in human gut microbiome composition have been proposed to be more robust markers of host health than cross-sectional variation. However, it is unclear how gut microbiome dynamics are influenced by chronic inflammatory conditions, such as inflammatory bowel disease (IBD), cancer, and obesity. Microbiome features, including species diversity and taxonomic composition, could be evaluated to assess the system’s capacity to resist (degree of change from baseline: resistance) and recover (ability to return to baseline: resilience) following a perturbation. By applying a perturbation to the gut environment, we can observe microbiome features at baseline and post-perturbation to assess both resistance and resilience. Although challenging to measure, resistance and resilience may be related to the health of the host. Given this, we aim to understand the utility of resistance and resilience as potential biomarkers of host health and treatment response in patients with chronic inflammation.
PB  - Oregon Health and Science University
PY  - 2024
T1  - Evaluating the utility of microbiome dynamics for predictive modeling: pathway to microbiome-mediated healthcare
TI  - Evaluating the utility of microbiome dynamics for predictive modeling: pathway to microbiome-mediated healthcare
UR  - https://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
Y1  - 2024
ER  -