000043576 001__ 43576
000043576 005__ 20240823145948.0
000043576 0247_ $$2doi$$a10.6083/bpxhc43576
000043576 037__ $$aIR
000043576 041__ $$aeng
000043576 245__ $$aEvaluating the utility of microbiome dynamics for predictive modeling: pathway to microbiome-mediated healthcare
000043576 260__ $$bOregon Health and Science University
000043576 269__ $$a2024
000043576 336__ $$aAbstract
000043576 520__ $$aRecently, longitudinal changes in human gut microbiome composition have been proposed to be more robust markers of host health than cross-sectional variation. However, it is unclear how gut microbiome dynamics are influenced by chronic inflammatory conditions, such as inflammatory bowel disease (IBD), cancer, and obesity. Microbiome features, including species diversity and taxonomic composition, could be evaluated to assess the system’s capacity to resist (degree of change from baseline: resistance) and recover (ability to return to baseline: resilience) following a perturbation. By applying a perturbation to the gut environment, we can observe microbiome features at baseline and post-perturbation to assess both resistance and resilience. Although challenging to measure, resistance and resilience may be related to the health of the host. Given this, we aim to understand the utility of resistance and resilience as potential biomarkers of host health and treatment response in patients with chronic inflammation.
000043576 540__ $$fCC BY
000043576 542__ $$fIn copyright - joint owners
000043576 650__ $$aGastrointestinal Microbiome$$011348
000043576 650__ $$aMicrobiota$$040384
000043576 650__ $$aInflammatory Bowel Diseases$$028222
000043576 650__ $$aObesity$$023118
000043576 6531_ $$ahuman gut microbiome
000043576 6531_ $$atemporal dynamics
000043576 6531_ $$aperturbations
000043576 6531_ $$achronic inflammation
000043576 691__ $$aSchool of Medicine$$041369
000043576 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000043576 7001_ $$aTurner, Christina$$uOregon Health and Science University$$041354
000043576 7001_ $$aGibbons, Sean$$uOregon Health and Science University$$041354
000043576 7001_ $$aMooney, Mike$$uOregon Health and Science University$$041354
000043576 7001_ $$aBoudreau, Eilis$$uOregon Health and Science University$$041354
000043576 7001_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354
000043576 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043576 8564_ $$9b817356a-6501-43c0-80ec-71f9304724c2$$s184386$$uhttps://digitalcollections.ohsu.edu/record/43576/files/ResearchWeek.2024.Turner.Christina.pdf
000043576 980__ $$aResearch Week