TY  - GEN
AB  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. Single-cell RNA sequencing (scRNA-seq) produces an abundance of data to analyze this process, facilitating insights into cellular processes related to treatment efficacy. However, due to the complexity of the process, contributions of other cell types to a process within a single cell type cannot be simply inferred. These results demonstrate that our analysis framework can identify potential mechanisms driving key cellular processes implicated in the failure of cancer immune checkpoint inhibitors. The framework can be applied to all cell types in the tumor immune microenvironment, expanding our understanding of key biological processes that underpin the effective treatment of cancer.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Klocke, Christopher
AU  - Moran, Amy E.
AU  - Adey, Andrew C.
AU  - McWeeney, Shannon K.
AU  - Wu, Guanming
DA  - 2024
DO  - 10.6083/bpxhc43577
DO  - doi
ID  - 43577
KW  - Computational Biology
KW  - Immunotherapy
KW  - Sequence Analysis, RNA
KW  - Gene Regulatory Networks
KW  - T-Cell Exhaustion
KW  - CD8-Positive T-Lymphocytes
KW  - bioinformatics
KW  - cancer immunology
KW  - scRNA-seq
L1  - https://digitalcollections.ohsu.edu/record/43577/files/ResearchWeek.2024.Klocke.Christopher.pdf
L2  - https://digitalcollections.ohsu.edu/record/43577/files/ResearchWeek.2024.Klocke.Christopher.pdf
L4  - https://digitalcollections.ohsu.edu/record/43577/files/ResearchWeek.2024.Klocke.Christopher.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43577/files/ResearchWeek.2024.Klocke.Christopher.pdf
N2  - Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, due to mechanisms that have yet to be fully characterized. The process of T cell exhaustion, by which T cells become dysfunctional in response to extended exposure to antigen, has been implicated in immunotherapy resistance. Single-cell RNA sequencing (scRNA-seq) produces an abundance of data to analyze this process, facilitating insights into cellular processes related to treatment efficacy. However, due to the complexity of the process, contributions of other cell types to a process within a single cell type cannot be simply inferred. These results demonstrate that our analysis framework can identify potential mechanisms driving key cellular processes implicated in the failure of cancer immune checkpoint inhibitors. The framework can be applied to all cell types in the tumor immune microenvironment, expanding our understanding of key biological processes that underpin the effective treatment of cancer.
PB  - Oregon Health and Science University
PY  - 2024
T1  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
TI  - Identification of cellular interactions in the tumor immune microenvironment underlying CD8 T cell exhaustion
UR  - https://digitalcollections.ohsu.edu/record/43577/files/ResearchWeek.2024.Klocke.Christopher.pdf
Y1  - 2024
ER  -