000043623 001__ 43623
000043623 005__ 20250424233627.0
000043623 0247_ $$2doi$$a10.6083/bpxhc43623
000043623 037__ $$aIR
000043623 041__ $$aeng
000043623 245__ $$aSingle-cell RNA sequencing analysis or irAE skin rash
000043623 260__ $$bOregon Health and Science University
000043623 269__ $$a2024
000043623 336__ $$aAbstract
000043623 520__ $$aImmune checkpoint inhibitor (ICI) therapies, such as anti-PD1 and anti-CTLA4, have proved to be clinically effective in numerous malignant diseases due to their ability to maintain immune surveillance of tumors by overriding the mechanisms in which lymphocytes establish peripheral tolerance. However, these therapies act in a systematic manner and thus may lead to autoimmune-like side effects termed immune-related adverse events (irAEs) in many organ systems that can ultimately halt treatment or lead to death. Therefore, understanding the underlying drivers of these irAEs is imperative in ensuring the quality of life and safety of our patients on ICI.
000043623 540__ $$fCC BY
000043623 542__ $$fIn copyright - joint owners
000043623 650__ $$aImmune Checkpoint Inhibitors$$013296
000043623 650__ $$aExanthema$$018763
000043623 650__ $$aSequence Analysis, RNA$$029959
000043623 650__ $$aLymphocytes$$021689
000043623 650__ $$aSkin Diseases$$026047
000043623 650__ $$aSingle-Cell Gene Expression Analysis$$013872
000043623 650__ $$aExanthema$$018763
000043623 6531_ $$aimmune-related adverse events
000043623 6531_ $$askin rash
000043623 6531_ $$asingle-cell RNA sequencing
000043623 691__ $$aSchool of Medicine$$041369
000043623 692__ $$aDepartment of Dermatology$$041406
000043623 7001_ $$aDoan, Khanh$$uOregon Health and Science University$$041354
000043623 7001_ $$aBranched, Heather$$uOregon Health and Science University$$041354
000043623 7001_ $$aClister, Terri$$uOregon Health and Science University$$041354
000043623 7001_ $$aFey, Rosalyn M.$$uOregon Health and Science University$$041354
000043623 7001_ $$aGarrison, Zach$$uOregon Health and Science University$$041354
000043623 7001_ $$aHall, Connor$$uOregon Health and Science University$$041354
000043623 7001_ $$aNichols, Rebecca$$uOregon Health and Science University$$041354
000043623 7001_ $$aKulkarni, Rajan$$uOregon Health and Science University$$041354
000043623 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043623 8564_ $$99c121915-8d8b-4054-8fa0-32f673c72997$$s99647$$uhttps://digitalcollections.ohsu.edu/record/43623/files/ResearchWeek.2024.Doan.Khanh.pdf$$ePublic$$275d7731e5aad7d6568f0b76729f62ac5$$31
000043623 980__ $$aResearch Week