TY  - GEN
N2  - Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology such as pruning of dendrites, axons, or synapses, which is mediated in part by non-neuronal cells called glia. While glia are known to be required for this process, we still have not defined how glia appropriately identify and eliminate only those synapses or neurites that require pruning. Given that many neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder (ASD) and Alzheimer’s Disease (AD) involve a major loss of synapses, and some glial pruning mechanisms appear to be inappropriately re-activated during disease, elucidating how glia accomplish these tasks will be crucial to finding therapeutic targets to prevent or reverse this loss. Thus, we sought to investigate which neuronal populations utilize astrocyte Crq to prune their synapses and to elucidate the mechanisms by which Crq mediates this process.
DO  - 10.6083/bpxhc43631
DO  - doi
AB  - Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology such as pruning of dendrites, axons, or synapses, which is mediated in part by non-neuronal cells called glia. While glia are known to be required for this process, we still have not defined how glia appropriately identify and eliminate only those synapses or neurites that require pruning. Given that many neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder (ASD) and Alzheimer’s Disease (AD) involve a major loss of synapses, and some glial pruning mechanisms appear to be inappropriately re-activated during disease, elucidating how glia accomplish these tasks will be crucial to finding therapeutic targets to prevent or reverse this loss. Thus, we sought to investigate which neuronal populations utilize astrocyte Crq to prune their synapses and to elucidate the mechanisms by which Crq mediates this process.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Astrocytic mechanisms of developmental synapse elimination in drosophila
DA  - 2024
AU  - Micael, Mariel K.
AU  - Jay, T.R.
AU  - Freeman, M.R.
L1  - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024
ID  - 43631
L4  - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
KW  - Alzheimer Disease
KW  - Autism Spectrum Disorder
KW  - Neuroglia
KW  - Synapses
KW  - Neuronal Plasticity
KW  - Drosophila
KW  - Immune System
KW  - Neuroglia
TI  - Astrocytic mechanisms of developmental synapse elimination in drosophila
Y1  - 2024
L2  - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
LK  - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
UR  - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
ER  -