TY - GEN AB - Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology such as pruning of dendrites, axons, or synapses, which is mediated in part by non-neuronal cells called glia. While glia are known to be required for this process, we still have not defined how glia appropriately identify and eliminate only those synapses or neurites that require pruning. Given that many neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder (ASD) and Alzheimer’s Disease (AD) involve a major loss of synapses, and some glial pruning mechanisms appear to be inappropriately re-activated during disease, elucidating how glia accomplish these tasks will be crucial to finding therapeutic targets to prevent or reverse this loss. Thus, we sought to investigate which neuronal populations utilize astrocyte Crq to prune their synapses and to elucidate the mechanisms by which Crq mediates this process. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Micael, Mariel K. AU - Jay, T.R. AU - Freeman, M.R. DA - 2024 DO - 10.6083/bpxhc43631 DO - doi ID - 43631 KW - Alzheimer Disease KW - Autism Spectrum Disorder KW - Neuroglia KW - Synapses KW - Neuronal Plasticity KW - Drosophila KW - Immune System KW - Neuroglia L1 - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf L2 - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf L4 - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf N2 - Neuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology such as pruning of dendrites, axons, or synapses, which is mediated in part by non-neuronal cells called glia. While glia are known to be required for this process, we still have not defined how glia appropriately identify and eliminate only those synapses or neurites that require pruning. Given that many neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder (ASD) and Alzheimer’s Disease (AD) involve a major loss of synapses, and some glial pruning mechanisms appear to be inappropriately re-activated during disease, elucidating how glia accomplish these tasks will be crucial to finding therapeutic targets to prevent or reverse this loss. Thus, we sought to investigate which neuronal populations utilize astrocyte Crq to prune their synapses and to elucidate the mechanisms by which Crq mediates this process. PB - Oregon Health and Science University PY - 2024 T1 - Astrocytic mechanisms of developmental synapse elimination in drosophila TI - Astrocytic mechanisms of developmental synapse elimination in drosophila UR - https://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf Y1 - 2024 ER -