000043631 001__ 43631
000043631 005__ 20240822145834.0
000043631 0247_ $$2doi$$a10.6083/bpxhc43631
000043631 037__ $$aIR
000043631 041__ $$aeng
000043631 245__ $$aAstrocytic mechanisms of developmental synapse elimination in drosophila
000043631 260__ $$bOregon Health and Science University
000043631 269__ $$a2024
000043631 336__ $$aAbstract
000043631 520__ $$aNeuronal remodeling is a crucial step towards healthy maturation of synapses, circuits and eventually brain function. This process involves changes in neuron morphology such as pruning of dendrites, axons, or synapses, which is mediated in part by non-neuronal cells called glia. While glia are known to be required for this process, we still have not defined how glia appropriately identify and eliminate only those synapses or neurites that require pruning. Given that many neurodevelopmental and neurodegenerative disorders such as autism spectrum disorder (ASD) and Alzheimer’s Disease (AD) involve a major loss of synapses, and some glial pruning mechanisms appear to be inappropriately re-activated during disease, elucidating how glia accomplish these tasks will be crucial to finding therapeutic targets to prevent or reverse this loss. Thus, we sought to investigate which neuronal populations utilize astrocyte Crq to prune their synapses and to elucidate the mechanisms by which Crq mediates this process.
000043631 540__ $$fCC BY
000043631 542__ $$fIn copyright - joint owners
000043631 650__ $$aAlzheimer Disease$$014513
000043631 650__ $$aAutism Spectrum Disorder$$011199
000043631 650__ $$aNeuroglia$$022841
000043631 650__ $$aSynapses$$026704
000043631 650__ $$aNeuronal Plasticity$$022857
000043631 650__ $$aDrosophila$$018058
000043631 650__ $$aImmune System$$020666
000043631 650__ $$aNeuroglia$$022841
000043631 7001_ $$aMicael, Mariel K.$$uOregon Health and Science University$$041354
000043631 7001_ $$aJay, T.R.$$uOregon Health and Science University$$041354
000043631 7001_ $$aFreeman, M.R.$$uOregon Health and Science University$$041354
000043631 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043631 8564_ $$96c3dc54a-c4e4-4fe6-9fc5-95bcb22d1e84$$s178502$$uhttps://digitalcollections.ohsu.edu/record/43631/files/ResearchWeek.2024.Micael.Mariel.pdf
000043631 980__ $$aResearch Week