@article{IR,
      recid = {43642},
      author = {Giske, Nicole and Smith, Nicholas R. and Swain, John and  Wu, Guanming and Wong, Melissa H.},
      title = {Dual states of Bmi1-expressing intestinal stem cells drive  epithelial development},
      publisher = {Oregon Health and Science University},
      address = {2024},
      number = {IR},
      abstract = {Tight regulation of the proliferative status of intestinal  stem cells is critical for establishing a functional  epithelial layer during development, a homeostatic state in  adulthood, and the ability to rapidly repair injury to  maintain the barrier to the outside environment. Our data  reveal functional differences in the Bmi1+ ISC across  development, with evidence that late stage Bmi1+ ISCs give  rise to differentiated cell lineages. Importantly, our data  provide the foundation for exploring an underlying  mechanism that regulates proliferative state of a stem cell  population in the intestine, with important implications on  development, injury repair and diseases such as cancer.},
      url = {http://digitalcollections.ohsu.edu/record/43642},
      doi = {https://doi.org/10.6083/bpxhc43642},
}