000043642 001__ 43642
000043642 005__ 20240822143311.0
000043642 0247_ $$2doi$$a10.6083/bpxhc43642
000043642 037__ $$aIR
000043642 041__ $$aeng
000043642 245__ $$aDual states of Bmi1-expressing intestinal stem cells drive epithelial development
000043642 260__ $$bOregon Health and Science University
000043642 269__ $$a2024
000043642 336__ $$aAbstract
000043642 520__ $$aTight regulation of the proliferative status of intestinal stem cells is critical for establishing a functional epithelial layer during development, a homeostatic state in adulthood, and the ability to rapidly repair injury to maintain the barrier to the outside environment. Our data reveal functional differences in the Bmi1+ ISC across development, with evidence that late stage Bmi1+ ISCs give rise to differentiated cell lineages. Importantly, our data provide the foundation for exploring an underlying mechanism that regulates proliferative state of a stem cell population in the intestine, with important implications on development, injury repair and diseases such as cancer.
000043642 540__ $$fCC BY
000043642 542__ $$fIn copyright - joint owners
000043642 650__ $$aStem Cells$$026391
000043642 650__ $$aIntestines$$020963
000043642 6531_ $$aBmi1
000043642 6531_ $$aintestinal stem cell
000043642 691__ $$aSchool of Medicine$$041369
000043642 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000043642 7001_ $$aGiske, Nicole$$uOregon Health and Science University$$041354
000043642 7001_ $$aSmith, Nicholas R.$$uOregon Health and Science University$$041354
000043642 7001_ $$aSwain, John$$uOregon Health and Science University$$041354
000043642 7001_ $$aWu, Guanming$$uOregon Health and Science University$$041354
000043642 7001_ $$aWong, Melissa H.$$uOregon Health and Science University$$041354
000043642 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043642 8564_ $$992444f2a-32d6-46a9-942b-1167667b87db$$s90746$$uhttps://digitalcollections.ohsu.edu/record/43642/files/ResearchWeek.2024.Giske.Nicole.pdf
000043642 980__ $$aResearch Week