@article{IR, author = {Kumar, Pramod and Wallstrum, Alyssa and Reda, Moataz and Wang, Ruijie and Ngamcherdtrakul, Worapol and Yantasee, Wassana}, url = {http://digitalcollections.ohsu.edu/record/43646}, title = {Nanoparticles co-delivering doxorubicin & pd-l1 inhibitor to induce immunogenic cell death and enhance anti-cancer immune response in lung cancer}, publisher = {Oregon Health and Science University}, abstract = {Non-small cell lung cancer (NSCLC) accounts for one in five of all cancer deaths worldwide. Most patients are diagnosed at advanced stages, resulting in a 5-year survival rate of less than 20%. Recently, immune checkpoint inhibitors (ICIs) for PD-L1 and PD-1 have received FDA approval for the treatment of NSCLC. However, only a small subset of patients (15-20%) respond to ICIs, and many of these responders eventually relapse. Doxorubicin (DOX) is an FDA-approved chemotherapeutic used in treating many cancers, including lung cancer. However, it has dose-dependent toxicity and patients develop resistance to DOX over time.}, number = {IR}, doi = {https://doi.org/10.6083/bpxhc43646}, recid = {43646}, address = {2024}, }