TY  - GEN
AB  - Tissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally highly specialized for their local environment and have been demonstrated to provide protective tissue immunosurveillance against infection and cancer.  Our data demonstrate the presence of TRM in these early tumors and points to the biomarker potential of these cells. In addition, our comprehensive transcriptomic analysis provides new insight into the evolution of the overall immune compartment in early primary melanomas.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Yadav, Rashi
AU  - Clister, Terri
AU  - Doan, Khanh
AU  - Yu, Wesley
AU  - Kulkarni, Rajan
AU  - Moreau, Joshua M.
DA  - 2024
DO  - 10.6083/bpxhc43651
DO  - doi
ID  - 43651
KW  - Melanoma
KW  - Memory T Cells
KW  - Skin Neoplasms
KW  - Biomarkers, Tumor
KW  - cancer immunology
KW  - tissue resident lymphocytes
KW  - early cancer biomarker
KW  - B cells
KW  - T cells
L1  - https://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf
L2  - https://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf
L4  - https://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf
N2  - Tissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally highly specialized for their local environment and have been demonstrated to provide protective tissue immunosurveillance against infection and cancer.  Our data demonstrate the presence of TRM in these early tumors and points to the biomarker potential of these cells. In addition, our comprehensive transcriptomic analysis provides new insight into the evolution of the overall immune compartment in early primary melanomas.
PB  - Oregon Health and Science University
PY  - 2024
T1  - Detecting and dissecting tissue resident memory T cells as an early melanoma biomarker
TI  - Detecting and dissecting tissue resident memory T cells as an early melanoma biomarker
UR  - https://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf
Y1  - 2024
ER  -