000043651 001__ 43651 000043651 005__ 20240822131106.0 000043651 0247_ $$2doi$$a10.6083/bpxhc43651 000043651 037__ $$aIR 000043651 041__ $$aeng 000043651 245__ $$aDetecting and dissecting tissue resident memory T cells as an early melanoma biomarker 000043651 260__ $$bOregon Health and Science University 000043651 269__ $$a2024 000043651 336__ $$aAbstract 000043651 520__ $$aTissue-resident memory T cells (TRM) are enriched in nonlymphoid barrier organs where they typically reside long-term without recirculating. These cells are functionally highly specialized for their local environment and have been demonstrated to provide protective tissue immunosurveillance against infection and cancer. Our data demonstrate the presence of TRM in these early tumors and points to the biomarker potential of these cells. In addition, our comprehensive transcriptomic analysis provides new insight into the evolution of the overall immune compartment in early primary melanomas. 000043651 540__ $$fCC BY 000043651 542__ $$fIn copyright - joint owners 000043651 650__ $$aMelanoma$$021989 000043651 650__ $$aMemory T Cells$$013784 000043651 650__ $$aSkin Neoplasms$$026054 000043651 650__ $$aBiomarkers, Tumor$$027501 000043651 6531_ $$acancer immunology 000043651 6531_ $$atissue resident lymphocytes 000043651 6531_ $$aearly cancer biomarker 000043651 6531_ $$aB cells 000043651 6531_ $$aT cells 000043651 692__ $$aCancer Early Detection Advanced Research Center$$041380 000043651 7001_ $$aYadav, Rashi$$uOregon Health and Science University$$041354 000043651 7001_ $$aClister, Terri$$uOregon Health and Science University$$041354 000043651 7001_ $$aDoan, Khanh$$uOregon Health and Science University$$041354 000043651 7001_ $$aYu, Wesley$$uOregon Health and Science University$$041354 000043651 7001_ $$aKulkarni, Rajan$$uOregon Health and Science University$$041354 000043651 7001_ $$aMoreau, Joshua M.$$uOregon Health and Science University$$041354 000043651 711__ $$aResearch Week$$uOregon Health and Science University$$d2024 000043651 8564_ $$9ffd06d87-aa6f-430f-9f30-570d4bc36eb9$$s88944$$uhttps://digitalcollections.ohsu.edu/record/43651/files/ResearchWeek.2024.Yadav.Rashi.pdf 000043651 980__ $$aResearch Week