TY  - GEN
AB  - Alphaviruses are arthropod-transmitted RNA viruses, including the NIAID Category B priority pathogens Eastern equine encephalitis (EEEV), Venezuelan equine encephalitis (VEEV) and chikungunya (CHIKV) viruses. In November of 2023, the first chikungunya virus vaccine became FDA approved for use in individuals 18 years of age and older who are at increased risk of exposure to CHIKV, although no FDA-licensed antiviral therapeutics are available to treat alphavirus infection or disease, thus demonstrating a need in the field of public health. We identified a small molecule antiviral hit using a screen against CHIKV.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Southern Research
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - University of North Carolina School of Medicine
AD  - University of Colorado School of Medicine
AD  - Southern Research
AD  - Oregon Health and Science University
AU  - Streblow, Zachary
AU  - Haese, Nicole N.
AU  - Streblow, Zachary J.
AU  - Garazan, Atefeh
AU  - Andoh, Takeshi
AU  - Bonin, Kiley
AU  - Streblow, Cassilyn E.
AU  - Denton, Michael
AU  - Medica, Samuel
AU  - Streblow, Gabriel J.
AU  - Kreklywich, Craig N.
AU  - Heise, Mark
AU  - Morrison, Thomas E.
AU  - Patek, Ashish
AU  - Streblow, Daniel N.
DA  - 2024
DO  - 10.6083/bpxhc43675
DO  - doi
ID  - 43675
KW  - Chikungunya virus
KW  - Alphavirus
KW  - RNA Viruses
KW  - Mice
KW  - antiviral inhibitors
KW  - mouse model
L1  - https://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
L2  - https://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
L4  - https://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
N2  - Alphaviruses are arthropod-transmitted RNA viruses, including the NIAID Category B priority pathogens Eastern equine encephalitis (EEEV), Venezuelan equine encephalitis (VEEV) and chikungunya (CHIKV) viruses. In November of 2023, the first chikungunya virus vaccine became FDA approved for use in individuals 18 years of age and older who are at increased risk of exposure to CHIKV, although no FDA-licensed antiviral therapeutics are available to treat alphavirus infection or disease, thus demonstrating a need in the field of public health. We identified a small molecule antiviral hit using a screen against CHIKV.
PB  - Oregon Health and Science University
PY  - 2024
T1  - 2-pyrimidone compound series prevents acute viremia and chronic chikungunya virus disease in a mouse model of infection
TI  - 2-pyrimidone compound series prevents acute viremia and chronic chikungunya virus disease in a mouse model of infection
UR  - https://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
Y1  - 2024
ER  -