000043675 001__ 43675
000043675 005__ 20240822080317.0
000043675 0247_ $$2doi$$a10.6083/bpxhc43675
000043675 037__ $$aIR
000043675 041__ $$aeng
000043675 245__ $$a2-pyrimidone compound series prevents acute viremia and chronic chikungunya virus disease in a mouse model of infection
000043675 260__ $$bOregon Health and Science University
000043675 269__ $$a2024
000043675 336__ $$aAbstract
000043675 520__ $$aAlphaviruses are arthropod-transmitted RNA viruses, including the NIAID Category B priority pathogens Eastern equine encephalitis (EEEV), Venezuelan equine encephalitis (VEEV) and chikungunya (CHIKV) viruses. In November of 2023, the first chikungunya virus vaccine became FDA approved for use in individuals 18 years of age and older who are at increased risk of exposure to CHIKV, although no FDA-licensed antiviral therapeutics are available to treat alphavirus infection or disease, thus demonstrating a need in the field of public health. We identified a small molecule antiviral hit using a screen against CHIKV.
000043675 540__ $$fCC BY
000043675 542__ $$fIn copyright - joint owners
000043675 650__ $$aChikungunya virus$$016460
000043675 650__ $$aAlphavirus$$014493
000043675 650__ $$aRNA Viruses$$025541
000043675 650__ $$aMice$$036842
000043675 6531_ $$aantiviral inhibitors
000043675 6531_ $$amouse model
000043675 692__ $$aVaccine and Gene Therapy Institute$$041508
000043675 7001_ $$aStreblow, Zachary$$uOregon Health and Science University$$041354
000043675 7001_ $$aHaese, Nicole N.$$uOregon Health and Science University$$041354
000043675 7001_ $$aStreblow, Zachary J.$$uOregon Health and Science University$$041354
000043675 7001_ $$aGarazan, Atefeh$$uSouthern Research
000043675 7001_ $$aAndoh, Takeshi$$uOregon Health and Science University$$041354
000043675 7001_ $$aBonin, Kiley$$uOregon Health and Science University$$041354
000043675 7001_ $$aStreblow, Cassilyn E.$$uOregon Health and Science University$$041354
000043675 7001_ $$aDenton, Michael$$uOregon Health and Science University$$041354
000043675 7001_ $$aMedica, Samuel$$uOregon Health and Science University$$041354
000043675 7001_ $$aStreblow, Gabriel J.$$uOregon Health and Science University$$041354
000043675 7001_ $$aKreklywich, Craig N.$$uOregon Health and Science University$$041354
000043675 7001_ $$aHeise, Mark$$uUniversity of North Carolina School of Medicine
000043675 7001_ $$aMorrison, Thomas E.$$uUniversity of Colorado School of Medicine
000043675 7001_ $$aPatek, Ashish$$uSouthern Research
000043675 7001_ $$aStreblow, Daniel N.$$uOregon Health and Science University$$041354
000043675 711__ $$aResearch Week$$uOregon Health and Science University$$d2024
000043675 8564_ $$90912d381-2aa0-47fd-9f95-44f22651378d$$s118234$$uhttps://digitalcollections.ohsu.edu/record/43675/files/ResearchWeek.2024.Streblow.Zachary.pdf
000043675 980__ $$aResearch Week