000043705 001__ 43705 000043705 005__ 20240919130343.0 000043705 0247_ $$2doi$$a10.6083/bpxhc43705 000043705 037__ $$aETD 000043705 041__ $$aeng 000043705 245__ $$aPanretinal optical coherence tomography 000043705 260__ $$bOregon Health and Science University 000043705 269__ $$a2024-09-23 000043705 336__ $$aDissertation 000043705 502__ $$bPh.D. 000043705 502__ $$gBiomedical Engineering 000043705 520__ $$aThis dissertation focuses on developing advanced handheld OCT and OCTA systems tailored for pediatric use, overcoming the limitations of traditional and commercially available devices. The work introduces prototypes with increased imaging speed and expanded field of view, enabling comprehensive visualization of the peripheral retina. These innovations significantly improve image quality and diagnostic capabilities, particularly for pediatric retinal diseases, including retinopathy of prematurity and retinoblastoma. The research demonstrates the potential of these systems to enhance pediatric ophthalmic care. 000043705 536__ $$oNIH$$c(P30 EY010572; R01 EY019474; R21 EY035816; R01 EY023285) 000043705 536__ $$oResearch to Prevent Blindness$$cCareer Advancement Award; Unrestricted departmental funding 000043705 536__ $$oBright Focus Foundation 000043705 540__ $$fCC BY 000043705 542__ $$fIn copyright - single owner 000043705 650__ $$aOptical Imaging$$039980 000043705 650__ $$aTomography, Optical Coherence$$035114 000043705 650__ $$aRetinopathy of Prematurity$$025405 000043705 651__ $$aOregon$$041094 000043705 6531_ $$ahandheld OCT 000043705 6531_ $$aoptical coherence tomography angiography 000043705 6531_ $$aperipheral imaging 000043705 6531_ $$aretinal imaging 000043705 6531_ $$apanretinal OCT 000043705 6531_ $$aultra-widefield imaging 000043705 691__ $$aSchool of Medicine$$041369 000043705 692__ $$aCasey Eye Institute$$041381 000043705 7001_ $$aNi, Shuibin$$uOregon Health and Science University$$041354$$10000-0003-3146-5006 000043705 7201_ $$aJian, Yifan$$uOregon Health and Science University$$041354$$eMentor$$7Personal 000043705 7201_ $$aCampbell, J. Peter$$uOregon Health and Science University$$041354$$eCommittee chair$$7Personal 000043705 7201_ $$aChen, Siyu$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal 000043705 7201_ $$aYoung, Benjamin K.$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal 000043705 7201_ $$aGibbs, Summer$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal 000043705 789__ $$eIs cited by$$wdoi: 10.1364/BOE.425411$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.1364/OL.443672$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.1364/OL.525364$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.1109/TMI.2023.3278269$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.1364/BOE.520739$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.3389/fped.2021.797684$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.1001/jamaophthalmol.2022.4173$$2DOI 000043705 789__ $$eIs cited by$$wdoi: 10.3389/fmed.2022.860371$$2DOI 000043705 792__ $$a<p>1. Ni S, Wei X, Ng R, Ostmo S, Chiang MF, Huang D, Jia Y, Campbell JP, Jian Y. High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source. Biomed Opt Express. 2021 May 20;12(6):3553-3570.</p> <p>2. Ni S, Nguyen TP, Ng R, Khan S, Ostmo S, Jia Y, Chiang MF, Huang D, Peter Campbell J, Jian Y. 105° field of view non-contact handheld swept-source optical coherence tomography. Opt Lett. 2021 Dec 1;46(23):5878-5881.</p> <p>3. Ni S, Ng R, Huang D, Chen S, Young BK, Peter Campbell J, Jian Y. Non-mydriatic ultra-widefield diffraction-limited retinal imaging. Opt Lett. 2024 Jul 15;49(14):3902-3905. </p> <p>4. Ni S, Nguyen TP, Ng R, Woodward M, Ostmo S, Jia Y, Chiang MF, Huang D, Skalet AH, Campbell JP, Jian Y. Panretinal Optical Coherence Tomography. IEEE Trans Med Imaging. 2023 Nov;42(11):3219-3228.</p> <p>5. Ni S, Liang GB, Ng R, Ostmo S, Jia Y, Chiang MF, Huang D, Skalet AH, Young BK, Campbell JP, Jian Y. Panretinal handheld OCT angiography for pediatric retinal imaging. Biomed Opt Express. 2024 Apr 29;15(5):3412-3424.</p> <p>6. Nguyen TP, Ni S, Khan S, Wei X, Ostmo S, Chiang MF, Jia Y, Huang D, Jian Y, Campbell JP. Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity. Front Pediatr. 2022 Jan 18;9:797684.</p> <p>7. Nguyen TP, Ni S, Ostmo S, Rajagopalan A, Coyner AS, Woodward M, Chiang MF, Jia Y, Huang D, Campbell JP, Jian Y. Association of Optical Coherence Tomography-Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity. JAMA Ophthalmol. 2022 Oct 13;140(11):1121–7.</p> <p>8. Nguyen TP, Ni S, Liang G, Khan S, Wei X, Skalet A, Ostmo S, Chiang MF, Jia Y, Huang D, Jian Y, Campbell JP. Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device. Front Med (Lausanne). 2022 Jul 4;9:860371.</p> 000043705 8564_ $$yPanretinal OCT$$944db1595-96e8-4bdf-b726-db2550f120e5$$s7544742$$uhttps://digitalcollections.ohsu.edu/record/43705/files/Ni.Shuibin.2024.pdf 000043705 909CO $$ooai:digitalcollections.ohsu.edu:43705$$pstudent-work 000043705 980__ $$aTheses and Dissertations 000043705 981__ $$aPublished$$b2024-09-18