TY  - GEN
AB  - Ischemic stroke is the most common type of stroke, accounting for about 87% of all stroke cases. Stroke is a leading cause of long-term disability and the second leading cause of death globally. Understanding the pathophysiology of ischemic stroke can improve early diagnosis and treatment, reduce neuronal damage, and improve recovery. Reactive astrogliosis and microglia are key features of stroke pathophysiology and may contribute to both neuroprotection and neurodysfunction. Here, we map the spatiotemporal progression of reactive astrogliosis through GFAP and vimentin labeling, and reactive microglia through Iba1 labeling. We found that reactive astrogliosis progresses faster and is more widespread than reactive microgliosis and that the astrocyte response is not entirely dependent on microglia. This response appears exacerbated in aging animals. This work also details preliminary findings linking reactive astrogliosis to impaired neurovascular coupling mechanisms after stroke and how this relates to developmental neurovascular coupling mechanisms.
AD  - Oregon Health and Science University
AU  - Stackhouse, Teresa
DA  - 9/16/2024
DO  - 10.6083/bpxhc43706
DO  - doi
ID  - 43706
KW  - Ischemic Stroke
KW  - Neurovascular Coupling
KW  - Astrocytes
KW  - Microglia
KW  - Neurovascular Coupling
KW  - reactive astrocytes
KW  - reactive microglia
L1  - https://digitalcollections.ohsu.edu/record/43706/files/Stackhouse.Teresa.2024.pdf
L2  - https://digitalcollections.ohsu.edu/record/43706/files/Stackhouse.Teresa.2024.pdf
L4  - https://digitalcollections.ohsu.edu/record/43706/files/Stackhouse.Teresa.2024.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43706/files/Stackhouse.Teresa.2024.pdf
N2  - Ischemic stroke is the most common type of stroke, accounting for about 87% of all stroke cases. Stroke is a leading cause of long-term disability and the second leading cause of death globally. Understanding the pathophysiology of ischemic stroke can improve early diagnosis and treatment, reduce neuronal damage, and improve recovery. Reactive astrogliosis and microglia are key features of stroke pathophysiology and may contribute to both neuroprotection and neurodysfunction. Here, we map the spatiotemporal progression of reactive astrogliosis through GFAP and vimentin labeling, and reactive microglia through Iba1 labeling. We found that reactive astrogliosis progresses faster and is more widespread than reactive microgliosis and that the astrocyte response is not entirely dependent on microglia. This response appears exacerbated in aging animals. This work also details preliminary findings linking reactive astrogliosis to impaired neurovascular coupling mechanisms after stroke and how this relates to developmental neurovascular coupling mechanisms.
PB  - Oregon Health and Science University
PY  - 9/16/2024
T1  - Spatiotemporal gradient of reactive astrogliosis reflects diminished neurovascular coupling after stroke
TI  - Spatiotemporal gradient of reactive astrogliosis reflects diminished neurovascular coupling after stroke
UR  - https://digitalcollections.ohsu.edu/record/43706/files/Stackhouse.Teresa.2024.pdf
Y1  - 9/16/2024
ER  -