@article{ETD, school = {Ph.D.}, author = {Klocke, Christopher}, url = {http://digitalcollections.ohsu.edu/record/43707}, title = {A novel computational framework for analyzing single-cell transcriptomics data: applications to T cell exhaustion and cancer immunotherapy response}, publisher = {Oregon Health and Science University}, abstract = {This novel computational framework for the analysis of single-cell gene expression data from human tumor samples enables the identification of molecular activity associated with CD8 T cell exhaustion across multiple cell types. It also provides the capability to consider these changes in the context of immunotherapy response. Its application yielded new insights into potential mechanisms of resistance to immune checkpoint inhibitor therapies in cancer patients. }, number = {ETD}, doi = {https://doi.org/10.6083/bpxhc43707}, recid = {43707}, address = {2024-09-18}, }