TY  - GEN
AB  - In this dissertation I explore applications of antibodies and alpaca-derived antibody fragments, known as VHHs, to understand severe acute respiratory associated coronavirus (SARS-CoV-2) biology and develop potential therapeutics against COVID-19. Here I study pre-existing SARS-CoV-1 antibodies for cross-reactivity with SARS-CoV-2 and design novel VHHs targeting the viral spike protein (S) and nucleocapsid protein (N). This work significantly advances our understanding of SARS-CoV-2 biology, highlighting the potential for antibody-based therapies and diagnostics against COVID-19 while also emphasizing the role antibodies can have in researching a newly emergent disease.
AD  - Oregon Health and Science University
AU  - Weinstein, Jules B.
DA  - 2024-09-18
DO  - 10.6083/bpxhc43708
DO  - doi
ED  - Tafesse, Fikadu G.
ED  - Barklis, Eric
ED  - Haigwood, Nancy
ED  - Messer, William
ED  - Pruneda, Jonathan
ED  - Academic advisor
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Editor
ID  - 43708
KW  - SARS-CoV-2
KW  - Antibodies
KW  - Single-Domain Antibodies
KW  - Coronavirus Nucleocapsid Proteins
KW  - Spike Glycoprotein, Coronavirus
KW  - Camelids, New World
KW  - VHH
KW  - nucleocapsid
L1  - https://digitalcollections.ohsu.edu/record/43708/files/Weinstein.Jules.2024.pdf
L2  - https://digitalcollections.ohsu.edu/record/43708/files/Weinstein.Jules.2024.pdf
L4  - https://digitalcollections.ohsu.edu/record/43708/files/Weinstein.Jules.2024.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/43708/files/Weinstein.Jules.2024.pdf
N2  - In this dissertation I explore applications of antibodies and alpaca-derived antibody fragments, known as VHHs, to understand severe acute respiratory associated coronavirus (SARS-CoV-2) biology and develop potential therapeutics against COVID-19. Here I study pre-existing SARS-CoV-1 antibodies for cross-reactivity with SARS-CoV-2 and design novel VHHs targeting the viral spike protein (S) and nucleocapsid protein (N). This work significantly advances our understanding of SARS-CoV-2 biology, highlighting the potential for antibody-based therapies and diagnostics against COVID-19 while also emphasizing the role antibodies can have in researching a newly emergent disease.
PB  - Oregon Health and Science University
PY  - 2024-09-18
T1  - Antiviral antibodies: interrogating SARS-CoV-2 replication with antibodies and VHHs
TI  - Antiviral antibodies: interrogating SARS-CoV-2 replication with antibodies and VHHs
UR  - https://digitalcollections.ohsu.edu/record/43708/files/Weinstein.Jules.2024.pdf
Y1  - 2024-09-18
ER  -