000043710 001__ 43710
000043710 005__ 20240920130349.0
000043710 0247_ $$2doi$$a10.6083/bpxhc43710
000043710 037__ $$aETD
000043710 041__ $$aeng
000043710 245__ $$aEvaluation of currently available 16S rRNA gene copy number correction software packages for accuracy and impact in a mock microbial community and urinary microbiome dataset
000043710 260__ $$bOregon Health and Science University
000043710 269__ $$a2024-06-21
000043710 336__ $$aCapstone
000043710 502__ $$bM.S.
000043710 502__ $$gBioinformatics & Computational Biomedicine
000043710 520__ $$aHere we evaluated the accuracy of several freely available software packages to correct for variable gene copy numbers in microbiome profiling using the 16S rRNA gene. We then applied these corrections to a published urinary microbiome dataset to show that the use of one of these packages has a measurable effect on the final results of human urinary microbiome studies.
000043710 540__ $$fNo License
000043710 542__ $$fIn copyright - joint owners
000043710 650__ $$aRNA, Ribosomal, 16S$$025549
000043710 650__ $$aGenes, rRNA$$032445
000043710 650__ $$aMicrobiota$$040384
000043710 6531_ $$amicrobiome profiling
000043710 6531_ $$a16S rRNA
000043710 6531_ $$agene copy number correction
000043710 691__ $$aSchool of Medicine$$041369
000043710 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000043710 7001_ $$aShah, Rebecca$$uOregon Health and Science University$$041354
000043710 7001_ $$aKarstens, Lisa$$uOregon Health and Science University$$041354
000043710 8564_ $$904887a72-a6eb-4477-9c03-601e2ece3f9e$$s757890$$uhttps://digitalcollections.ohsu.edu/record/43710/files/Shah.Karstens.2024.pdf
000043710 909CO $$ooai:digitalcollections.ohsu.edu:43710$$pstudent-work
000043710 980__ $$aTheses and Dissertations
000043710 981__ $$aPublished$$b2024-09-20