@article{ETD, recid = {43713}, author = {Rose, Elizabeth}, title = {Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2024-09-20}, number = {ETD}, abstract = {This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next generation sequencing approaches. It also contains novel findings of how Polo-like kinase family inhibition can lead to neuroprotection of cortical neurons bearing alpha-synuclein lewy pathology in a Parkinson's Disease mouse model using an in vivo imaging technique. }, url = {http://digitalcollections.ohsu.edu/record/43713}, doi = {https://doi.org/10.6083/bpxhc43713}, }