TY  - GEN
N2  - This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next generation sequencing approaches. It also contains novel findings of how Polo-like kinase family inhibition can lead to neuroprotection of cortical neurons bearing alpha-synuclein lewy pathology in a Parkinson's Disease mouse model using an in vivo imaging technique. 
DO  - 10.6083/bpxhc43713
DO  - doi
AB  - This dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next generation sequencing approaches. It also contains novel findings of how Polo-like kinase family inhibition can lead to neuroprotection of cortical neurons bearing alpha-synuclein lewy pathology in a Parkinson's Disease mouse model using an in vivo imaging technique. 
AD  - Oregon Health and Science University
T1  - Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner
DA  - 2024-09-20
AU  - Rose, Elizabeth
L1  - https://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2024-09-20
ID  - 43713
L4  - https://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
KW  - alpha-Synuclein
KW  - Parkinson Disease
KW  - Lewy Body Disease
KW  - DNA Repair
KW  - DNA double strand break repair
KW  - Lewy pathology
TI  - Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner
Y1  - 2024-09-20
L2  - https://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
LK  - https://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
UR  - https://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
ER  -