000043713 001__ 43713
000043713 005__ 20240923130414.0
000043713 0247_ $$2doi$$a10.6083/bpxhc43713
000043713 037__ $$aETD
000043713 041__ $$aeng
000043713 245__ $$aAlpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner
000043713 260__ $$bOregon Health and Science University
000043713 269__ $$a2024-09-20
000043713 336__ $$aDissertation
000043713 502__ $$bPh.D.
000043713 502__ $$gNeuroscience
000043713 520__ $$aThis dissertation investigates the role of alpha-synuclein in DNA double-strand break repair, specifically non-homologous end joining via CRISPR/Cas9 lentiviral and next generation sequencing approaches. It also contains novel findings of how Polo-like kinase family inhibition can lead to neuroprotection of cortical neurons bearing alpha-synuclein lewy pathology in a Parkinson's Disease mouse model using an in vivo imaging technique. 
000043713 540__ $$fCC BY-NC
000043713 542__ $$fIn copyright - single owner
000043713 650__ $$aalpha-Synuclein$$037032
000043713 650__ $$aParkinson Disease$$023617
000043713 650__ $$aLewy Body Disease$$032845
000043713 650__ $$aDNA Repair$$017990
000043713 6531_ $$aDNA double strand break repair
000043713 6531_ $$aLewy pathology
000043713 691__ $$aSchool of Medicine$$041369
000043713 692__ $$aDepartment of Neurology$$041431
000043713 7001_ $$aRose, Elizabeth$$uOregon Health and Science University$$041354$$10000-0003-3999-0526
000043713 8564_ $$9053cb084-ed7a-438f-a777-6261a6fe5559$$s15831712$$uhttps://digitalcollections.ohsu.edu/record/43713/files/Rose.Elizabeth.2024.pdf
000043713 909CO $$ooai:digitalcollections.ohsu.edu:43713$$pstudent-work
000043713 980__ $$aTheses and Dissertations
000043713 981__ $$aPublished$$b2024-09-23