000044106 001__ 44106 000044106 005__ 20241220131333.0 000044106 0247_ $$2doi$$a10.6083/bpxhc44106 000044106 037__ $$aETD 000044106 041__ $$aeng 000044106 245__ $$aInsight into the cellular and molecular mechanisms of melanoma-associated retinopathy 000044106 260__ $$bOregon Health and Science University 000044106 269__ $$a2024-11-12 000044106 336__ $$aDissertation 000044106 502__ $$gPhysiology & Pharmacology (sunsetting) 000044106 502__ $$bPh.D. 000044106 520__ $$aThis dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Through the analysis of a MAR patient's disease evolution and the development and implementation of a novel bioassay, this text contributes substantially to our understanding of MAR pathology. These clinical findings may shape future MAR diagnosis and treatment, and the mechanism discoveries may guide strategies for therapeutic intervention or disease prevention. 000044106 536__ $$oNIH$$c1-R01-EY031596-01 000044106 540__ $$fCC BY 000044106 542__ $$fIn copyright - other owner 000044106 650__ $$aParaneoplastic Syndromes, Ocular$$039592 000044106 650__ $$aBlood-Retinal Barrier$$015688 000044106 650__ $$aRetinal Neurons$$038255 000044106 650__ $$aEndocytosis$$018417 000044106 650__ $$aAutoantibodies$$015233 000044106 650__ $$aMelanoma$$021989 000044106 650__ $$aRetinal Bipolar Cells$$036781 000044106 650__ $$aRetina$$025387 000044106 650__ $$aAutoimmunity$$028491 000044106 651__ $$aOregon$$041094 000044106 6531_ $$amelanoma-associated retinopathy 000044106 691__ $$aSchool of Medicine$$041369 000044106 692__ $$aDepartment of Chemical Physiology and Biochemistry$$041400 000044106 7001_ $$aMosavi-Hecht, Ryan$$uOregon Health and Science University$$041354$$10000-0001-7925-1758 000044106 7201_ $$aMorgans, Catherine$$uOregon Health and Science University$$041354$$10000-0002-7287-3447$$eMentor$$7Personal 000044106 7201_ $$aDuvoisin, Robert$$uOregon Health and Science University$$041354$$eCo-Mentor$$7Personal 000044106 7201_ $$aSaugstad, Julie$$uOregon Health and Science University$$041354$$10000-0002-2996-9611$$eCommittee chair$$7Personal 000044106 7201_ $$aYang, Paul$$uOregon Health and Science University$$041354$$10000-0003-2294-0979$$eCommittee member$$7Personal 000044106 7201_ $$aHeyer, Barrett$$uOregon Health and Science University$$041354$$eOther$$7Personal 000044106 7201_ $$aRosenberg, Christopher$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aWhite, Elizabeth$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aBerry, Elizabeth$$uOregon Health and Science University$$041354$$10000-0002-7574-6718$$eCommittee member$$7Personal 000044106 7201_ $$aShi, Qing$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aGarrett, Tavita$$uOregon Health and Science University$$041354$$10000-0002-2585-4251$$eCollaborator$$7Personal 000044106 7201_ $$aSivyer, Benjamin$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aHaley, Tammie$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aRen, Gaoying$$uOregon Health and Science University$$041354$$eCollaborator$$7Personal 000044106 7201_ $$aCarroll, James$$uOregon Health and Science University$$041354$$10000-0002-9264-4502$$eCollaborator$$7Personal 000044106 7201_ $$aAicher, Sue$$uOregon Health and Science University$$041354$$10000-0001-5310-4055$$eCollaborator$$7Personal 000044106 789__ $$eIs part of$$w10.3389/fopht.2023.1226224 $$2DOI 000044106 789__ $$eIs part of$$w10.3791/65757$$2DOI 000044106 789__ $$eIs part of$$w10.3389/fmed.2024.1445180$$2DOI 000044106 792__ $$a<p>1. Mosavi-Hecht RM, Yang P, Heyer B, Rosenberg CR, White E, Berry EG, et al. Case report: Longitudinal evaluation and treatment of a melanoma-associated retinopathy patient. Front Med [Internet]. 2024 Sep 10 [cited 2024 Sep 12];11. Available from: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1445180/full</p> <p>2. Hecht RM, Shi Q, Garrett TR, Sivyer B, Morgans C. Split Retina as an Improved Flatmount Preparation for Studying Inner Nuclear Layer Neurons in Vertebrate Retina. J Vis Exp. 2024 Jan 16;(203):e65757. </p> <p>3. Haley TL, Hecht RM, Ren G, Carroll JR, Aicher SA, Duvoisin RM, et al. Light-dependent changes in the outer plexiform layer of the mouse retina. Frontiers in Ophthalmology [Internet]. 2023 [cited 2023 Oct 10];3. Available from: https://www.frontiersin.org/articles/10.3389/fopht.2023.1226224</p> 000044106 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44106/files/MosaviHecht.Ryan_Wiley_License.pdf$$yReuse license for content originally published by John Wiley and Sons$$93c3d34da-1c56-4c33-aa6e-5025ba622010$$s81680 000044106 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44106/files/MosaviHecht.Ryan.2024.pdf$$yDissertation$$9822d2e0e-be24-42ef-adf0-29104f474168$$s67079829 000044106 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44106/files/MosaviHecht.Ryan_Additional_File%281%29.pdf$$yAdditional File 1$$981616a52-4904-4da9-b6f6-6f49148cad0d$$s91611 000044106 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44106/files/MosaviHecht.Ryan_Additional_File%282%29.pdf$$yAdditional File 2$$9078cfb73-5b07-466a-81de-78a79f897184$$s2593463 000044106 909CO $$ooai:digitalcollections.ohsu.edu:44106$$pstudent-work 000044106 980__ $$aTheses and Dissertations 000044106 981__ $$aPublished$$b2024-12-19