@article{ETD,
      recid = {44107},
      author = {Huynh, Katherine  and Schilling, Kevin  and Speese, Sean   and Schutt, Carolyn and Armstrong, Randall and Lowrey,  Mary},
      title = {Ultrasound-responsive gene delivery biomaterials for  modeling breast cancer progression in the 3D  microenvironment},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2024-12-19},
      number = {ETD},
      abstract = {Tumors overexpressing the HER2 oncogene account for around  20% of breast cancer cases and are associated with  aggressive disease. These tumors generally originate from a  small subset of HER2 oncogene-overexpressing cells within  the 3D tissue microenvironment, but little is known about  the cellular interactions that occur at these early stages  of disease development. There is a need to better model the  earliest stages of cancer progression which requires the  development of new methods to control the expression of  oncogenes within a 3D tissue scaffold system. To address  this challenge, this dissertation develops a new 3D  ultrasound-responsive biomaterial platform and accompanying  characterization techniques to model early cancer  progression in cells and spheroids within 3D matrix  microenvironments.},
      url = {http://digitalcollections.ohsu.edu/record/44107},
      doi = {https://doi.org/10.6083/bpxhc44107},
}