TY  - GEN
AB  - Tumors overexpressing the HER2 oncogene account for around 20% of breast cancer cases and are associated with aggressive disease. These tumors generally originate from a small subset of HER2 oncogene-overexpressing cells within the 3D tissue microenvironment, but little is known about the cellular interactions that occur at these early stages of disease development. There is a need to better model the earliest stages of cancer progression which requires the development of new methods to control the expression of oncogenes within a 3D tissue scaffold system. To address this challenge, this dissertation develops a new 3D ultrasound-responsive biomaterial platform and accompanying characterization techniques to model early cancer progression in cells and spheroids within 3D matrix microenvironments.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Huynh, Katherine 
AU  - Schilling, Kevin 
AU  - Speese, Sean 
AU  - Schutt, Carolyn
AU  - Armstrong, Randall
AU  - Lowrey, Mary
DA  - 2024-12-19
DO  - 10.6083/bpxhc44107
DO  - doi
ED  - Hinds, Monica
ED  - Ibsen, Carolyn Schutt
ED  - Ibsen, Stuart
ED  - Olson, Susan
ED  - Branchaud, Bruce
ED  - Chair
ED  - Advisor
ED  - Committee member
ED  - Committee member
ED  - Committee member
ID  - 44107
KW  - Biocompatible Materials
KW  - Hydrogels
KW  - Microbubbles
KW  - Tissue Scaffolds
KW  - Microwaves
KW  - Oncogenes
KW  - Transfection
KW  - Genes, erbB-2
KW  - Breast Neoplasms
KW  - ultrasound 
KW  - 3D tumor model
KW  - HER2 oncogene
KW  - energy responsive biomaterials
KW  - zeta potential
KW  - microwave-assisted immunostaining
KW  - breast cancer
L1  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf
L1  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf
L2  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf
L2  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf
L4  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf
L4  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf
LK  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf
N2  - Tumors overexpressing the HER2 oncogene account for around 20% of breast cancer cases and are associated with aggressive disease. These tumors generally originate from a small subset of HER2 oncogene-overexpressing cells within the 3D tissue microenvironment, but little is known about the cellular interactions that occur at these early stages of disease development. There is a need to better model the earliest stages of cancer progression which requires the development of new methods to control the expression of oncogenes within a 3D tissue scaffold system. To address this challenge, this dissertation develops a new 3D ultrasound-responsive biomaterial platform and accompanying characterization techniques to model early cancer progression in cells and spheroids within 3D matrix microenvironments.
PB  - Oregon Health and Science University
PY  - 2024-12-19
T1  - Ultrasound-responsive gene delivery biomaterials for modeling breast cancer progression in the 3D microenvironment
TI  - Ultrasound-responsive gene delivery biomaterials for modeling breast cancer progression in the 3D microenvironment
UR  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf
UR  - https://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf
Y1  - 2024-12-19
ER  -