000044107 001__ 44107
000044107 005__ 20241220131333.0
000044107 0247_ $$2doi$$a10.6083/bpxhc44107
000044107 037__ $$aETD
000044107 041__ $$aeng
000044107 245__ $$aUltrasound-responsive gene delivery biomaterials for modeling breast cancer progression in the 3D microenvironment
000044107 260__ $$bOregon Health and Science University
000044107 269__ $$a2024-12-19
000044107 336__ $$aDissertation
000044107 502__ $$gBiomedical Engineering
000044107 502__ $$bPh.D.
000044107 520__ $$aTumors overexpressing the HER2 oncogene account for around 20% of breast cancer cases and are associated with aggressive disease. These tumors generally originate from a small subset of HER2 oncogene-overexpressing cells within the 3D tissue microenvironment, but little is known about the cellular interactions that occur at these early stages of disease development. There is a need to better model the earliest stages of cancer progression which requires the development of new methods to control the expression of oncogenes within a 3D tissue scaffold system. To address this challenge, this dissertation develops a new 3D ultrasound-responsive biomaterial platform and accompanying characterization techniques to model early cancer progression in cells and spheroids within 3D matrix microenvironments.
000044107 536__ $$oNational Institute of General Medical Sciences (NIGMS) of the National Institutes of Health $$cR35GM151057
000044107 536__ $$oNational Science Foundation $$c2339254
000044107 536__ $$oNational Institute of Health (NIH)$$cP30 CA069533
000044107 536__ $$oKnight Cancer Institute’s Cancer Early Detection Advanced Research Center (CEDAR)$$cExploratory7270220; Exploratory6280819; Manuscript Prep 2022-1674; Manuscript Prep 2022-1686; Full 2021-1308; Full6270819; 
000044107 540__ $$fCC BY
000044107 542__ $$fIn copyright - joint owners
000044107 650__ $$aBiocompatible Materials$$015550
000044107 650__ $$aHydrogels$$032129
000044107 650__ $$aMicrobubbles$$035635
000044107 650__ $$aTissue Scaffolds$$037854
000044107 650__ $$aMicrowaves$$022301
000044107 650__ $$aOncogenes$$023203
000044107 650__ $$aTransfection$$027260
000044107 650__ $$aGenes, erbB-2$$031052
000044107 650__ $$aBreast Neoplasms$$015809
000044107 6531_ $$aultrasound 
000044107 6531_ $$a3D tumor model
000044107 6531_ $$aHER2 oncogene
000044107 6531_ $$aenergy responsive biomaterials
000044107 6531_ $$azeta potential
000044107 6531_ $$amicrowave-assisted immunostaining
000044107 6531_ $$abreast cancer
000044107 691__ $$aSchool of Medicine$$041369
000044107 692__ $$aDepartment of Biomedical Engineering$$041397
000044107 7001_ $$aHuynh, Katherine $$uOregon Health and Science University$$041354$$10000-0003-3989-872X
000044107 7001_ $$aSchilling, Kevin $$uOregon Health and Science University$$041354$$10000-0001-7806-4117
000044107 7001_ $$aSpeese, Sean $$uOregon Health and Science University$$041354$$10000-0002-3965-9828
000044107 7001_ $$aSchutt, Carolyn$$uOregon Health and Science University$$041354$$10000-0002-6614-052X
000044107 7001_ $$aArmstrong, Randall$$uOregon Health and Science University$$041354$$10009-0006-7547-0770
000044107 7001_ $$aLowrey, Mary$$uOregon Health and Science University$$041354$$10000-0002-8051-5869
000044107 7201_ $$aHinds, Monica$$uOregon Health and Science University$$041354$$eChair$$7Personal
000044107 7201_ $$aIbsen, Carolyn Schutt$$uOregon Health and Science University$$041354$$10000-0002-6614-052X$$eAdvisor$$7Personal
000044107 7201_ $$aIbsen, Stuart$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000044107 7201_ $$aOlson, Susan$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000044107 7201_ $$aBranchaud, Bruce$$uOregon Health and Science University$$041354$$eCommittee member$$7Personal
000044107 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024_Citation%20Permission%20Form%20Fundamentals%20of%20Medical%20Ultrasonics%20for%20Dissertation%20Use.pdf$$9c2da6844-3cec-4f4e-a62e-6b749351e9eb$$s274428
000044107 8564_ $$uhttps://digitalcollections.ohsu.edu/record/44107/files/Huynh.Katherine.2024.pdf$$9db6909aa-16d3-47b4-b940-b5cb2ebbecc5$$s4827346
000044107 909CO $$ooai:digitalcollections.ohsu.edu:44107$$pstudent-work
000044107 980__ $$aTheses and Dissertations
000044107 981__ $$aPublished$$b2024-12-20