000000442 001__ 442
000000442 005__ 20260420114803.0
000000442 0247_ $$2DOI$$a10.6083/M4RB72K6
000000442 037__ $$aETD
000000442 245__ $$aAnalysis of HIV-1 gag matrix and capsid domain mutations and their effects on virus assembly and infectivity
000000442 260__ $$aOregon Health and Science University
000000442 269__ $$a2007
000000442 336__ $$aDissertation
000000442 502__ $$bPh.D.
000000442 520__ $$aThis work investigates the molecular interactions critical to the assembly and maturation of human immunodeficiency virus type 1 (HIV‑1). The production of infectious virions requires precisely coordinated protein–protein, protein–membrane, and protein–nucleic acid interactions. In particular, the PrGag and PrGag‑Pol polyproteins must be correctly targeted to cellular assembly sites, interact in a regulated manner, and bud from the host cell. Subsequent proteolytic processing of these polyproteins is essential for virion maturation and infectivity.
000000442 540__ $$fCC BY
000000442 542__ $$fIn copyright - single owner
000000442 650__ $$aCapsid$$016051
000000442 650__ $$aVirus Assembly$$031327
000000442 650__ $$aViral Structural Proteins$$028569
000000442 650__ $$aViral Nonstructural Proteins$$029909
000000442 650__ $$aAntiviral Agents$$014937
000000442 650__ $$aHIV-1$$028454
000000442 691__ $$aSchool of Medicine$$041369
000000442 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000442 7001_ $$aScholz, Isabel$$uOregon Health and Science University$$041354
000000442 7201_ $$aBarklis, Eric$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000442 8564_ $$919d0aede-d291-4edd-b14f-b5015953ac9f$$s6077535$$uhttps://digitalcollections.ohsu.edu/record/442/files/443_etd.pdf$$ePublic$$23154e1640398e8f0ff9168735124e286$$31
000000442 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000442 905__ $$a/rest/prod/fj/23/62/11/fj2362114
000000442 909CO $$ooai:digitalcollections.ohsu.edu:442$$pstudent-work
000000442 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000442 980__ $$aTheses and Dissertations