000000452 001__ 452
000000452 005__ 20260410124447.0
000000452 0247_ $$2DOI$$a10.6083/M4FX77D3
000000452 037__ $$aETD
000000452 245__ $$aDevelopmental regulation of melanopsin-containing retinal ganglion cells and its effects on circadian function
000000452 260__ $$aOregon Health and Science University
000000452 269__ $$a2008
000000452 336__ $$aDissertation
000000452 502__ $$bPh.D.
000000452 502__ $$gNeuroscience
000000452 520__ $$aLight input from the retina entrains the circadian clock in the suprachiasmatic nucleus via melanopsin‑expressing intrinsically photosensitive retinal ganglion cells (ipRGCs). This study tested whether outer retinal development influences ipRGC maturation and adult circadian function using retinally degenerate CBA/J mice. Behavioral assays revealed impaired photoentrainment despite intact melanopsin signaling at the retinal level. Photoreceptor loss increased ipRGC numbers without altering their morphology, suggesting regulation of developmental cell death. Central analyses showed alterations in SCN neuropeptide composition and enhanced light‑induced activation. Together, these findings indicate that visual system maturation shapes central circadian circuitry and behavior.
000000452 540__ $$fCC BY
000000452 542__ $$fIn copyright - single owner
000000452 650__ $$aCircadian Rhythm$$016745
000000452 650__ $$aPhysiology$$024123
000000452 650__ $$aRetinal Cone Photoreceptor Cells$$030372
000000452 650__ $$aRetinal Ganglion Cells$$025392
000000452 650__ $$aRetinal Rod Photoreceptor Cells$$030371
000000452 650__ $$aVirulence Factors$$034836
000000452 650__ $$aMice, Inbred CBA$$022239
000000452 650__ $$amelanopsin
000000452 650__ $$aSuprachiasmatic Nucleus$$026635
000000452 650__ $$aCircadian Clocks$$039026
000000452 691__ $$aSchool of Medicine$$041369
000000452 692__ $$aVollum Institute$$041509
000000452 7001_ $$aRuggiero, Linda$$uOregon Health and Science University$$041354
000000452 7201_ $$aRobinson, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000452 8564_ $$95291b0f6-daf5-4a87-8237-39463a4b48cd$$s1863408$$uhttps://digitalcollections.ohsu.edu/record/452/files/453_etd.pdf$$ePublic$$23183d9423b5f7742a8f7cd415ef4b055$$31
000000452 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000452 905__ $$a/rest/prod/15/44/bp/10/1544bp10f
000000452 909CO $$ooai:digitalcollections.ohsu.edu:452$$pstudent-work
000000452 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000452 980__ $$aTheses and Dissertations