The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells and provides resistance to immunotherapy. While the abundance of tumor-extrinsic fibrotic stroma and suppressive myeloid populations has been extensively studied in mediating PDAC immune evasion, the role of tumor-intrinsic post-transcriptional gene regulation in driving tumor-immune crosstalk has been relatively unexplored. Here, we report that the RNA-binding protein, HuR (ELAVL1), is enriched in human PDAC and negatively correlates with T cell infiltration.
