000000468 001__ 468
000000468 005__ 20250424232525.0
000000468 0247_ $$2DOI$$a10.6083/M4CZ354W
000000468 037__ $$aETD
000000468 245__ $$aNovel bioinformatics methods for identification and quantification of deamidation in shotgun proteomics experiments
000000468 260__ $$bOregon Health and Science University
000000468 269__ $$a2008
000000468 336__ $$aDissertation
000000468 502__ $$bPh.D.
000000468 520__ $$aReliable  identification of  deamidation  remains  challenging  when  using  low-resolution  mass  spectrometry  due  to  the  MS/MS  mis-triggers  on  first  isotopic  peak  of unmodified peptide and limited mass resolution. We developed a bioinformatics method  that  utilizes  differential  chromatographic  behavior and  corrected  peptide  masses  of  the amidated  and  deamidated  peptides  to  validate  deamidation  identifications.
000000468 540__ $$fCC BY
000000468 542__ $$fIn copyright - single owner
000000468 650__ $$aChromatography$$016653
000000468 650__ $$aProteomics$$035059
000000468 650__ $$aComputational Biology$$031511
000000468 650__ $$aProtein Processing, Post-Translational$$024757
000000468 650__ $$aLens, Crystalline$$021406
000000468 650__ $$aLiquid Crystals$$036610
000000468 691__ $$aSchool of Medicine$$041369
000000468 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000000468 7001_ $$aDasari, Surendra$$uOregon Health and Science University$$041354
000000468 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eCommittee chair
000000468 8564_ $$9224b36ed-c5c3-4f3c-9dd3-c9b1d1c7851e$$s2737923$$uhttps://digitalcollections.ohsu.edu/record/468/files/469_etd.pdf$$ePublic$$25d4a21bf45fef2628ee993f87bb41b2d$$31
000000468 905__ $$a/rest/prod/1c/18/df/79/1c18df79x
000000468 909CO $$ooai:digitalcollections.ohsu.edu:468$$pstudent-work
000000468 980__ $$aBiomedical Informatics