@article{ETD,
      recid = {481},
      author = {Rein, Chantelle},
      title = {Genetic regulation of the expression of two fibrinogen  gamma chain splice variants by fibrin degeneration products  and inflammatory cytokines},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2010},
      number = {ETD},
      abstract = {Fibrinogen and its γ’ isoform are key predictors of  cardiovascular disease, yet the mechanisms regulating their  production are not fully defined. This work identifies  IFN‑γ as a novel suppressor of total fibrinogen via STAT1  and its interference with IL‑6 signaling. IL‑6, IFN‑γ, and  TNF‑α are shown to differentially modulate γ’ versus total  fibrinogen. We also demonstrate that D‑dimer enters  hepatocyte‑derived cells and decreases γ’ fibrinogen  synthesis. Finally, we characterize a γR275C fibrinogen  mutation that produces a hemorrhagic phenotype, revealing  its pathogenic potential.},
      url = {http://digitalcollections.ohsu.edu/record/481},
      doi = {https://doi.org/10.6083/M4Q81B2H},
}