TY  - GEN
AB  - Fibrinogen and its γ’ isoform are key predictors of cardiovascular disease, yet the mechanisms regulating their production are not fully defined. This work identifies IFN‑γ as a novel suppressor of total fibrinogen via STAT1 and its interference with IL‑6 signaling. IL‑6, IFN‑γ, and TNF‑α are shown to differentially modulate γ’ versus total fibrinogen. We also demonstrate that D‑dimer enters hepatocyte‑derived cells and decreases γ’ fibrinogen synthesis. Finally, we characterize a γR275C fibrinogen mutation that produces a hemorrhagic phenotype, revealing its pathogenic potential.
AD  - Oregon Health and Science University
AU  - Rein, Chantelle
DA  - 2010
DO  - 10.6083/M4Q81B2H
DO  - DOI
ED  - Farrell, David
ED  - Advisor
ED  - Mentor
ID  - 481
KW  - Fibrinogen
KW  - Blood Proteins
KW  - Blood Coagulation
KW  - Cytokines
KW  - Interleukin-6
KW  - Cardiovascular Diseases
L1  - https://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf
N2  - Fibrinogen and its γ’ isoform are key predictors of cardiovascular disease, yet the mechanisms regulating their production are not fully defined. This work identifies IFN‑γ as a novel suppressor of total fibrinogen via STAT1 and its interference with IL‑6 signaling. IL‑6, IFN‑γ, and TNF‑α are shown to differentially modulate γ’ versus total fibrinogen. We also demonstrate that D‑dimer enters hepatocyte‑derived cells and decreases γ’ fibrinogen synthesis. Finally, we characterize a γR275C fibrinogen mutation that produces a hemorrhagic phenotype, revealing its pathogenic potential.
PB  - Oregon Health and Science University
PY  - 2010
T1  - Genetic regulation of the expression of two fibrinogen gamma chain splice variants by fibrin degeneration products and inflammatory cytokines
TI  - Genetic regulation of the expression of two fibrinogen gamma chain splice variants by fibrin degeneration products and inflammatory cytokines
UR  - https://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf
Y1  - 2010
ER  -