000000481 001__ 481
000000481 005__ 20260219075432.0
000000481 0247_ $$2DOI$$a10.6083/M4Q81B2H
000000481 037__ $$aETD
000000481 245__ $$aGenetic regulation of the expression of two fibrinogen gamma chain splice variants by fibrin degeneration products and inflammatory cytokines
000000481 260__ $$bOregon Health and Science University
000000481 269__ $$a2010
000000481 336__ $$aDissertation
000000481 502__ $$bPh.D.
000000481 520__ $$aFibrinogen and its γ’ isoform are key predictors of cardiovascular disease, yet the mechanisms regulating their production are not fully defined. This work identifies IFN‑γ as a novel suppressor of total fibrinogen via STAT1 and its interference with IL‑6 signaling. IL‑6, IFN‑γ, and TNF‑α are shown to differentially modulate γ’ versus total fibrinogen. We also demonstrate that D‑dimer enters hepatocyte‑derived cells and decreases γ’ fibrinogen synthesis. Finally, we characterize a γR275C fibrinogen mutation that produces a hemorrhagic phenotype, revealing its pathogenic potential.
000000481 540__ $$fCC BY
000000481 542__ $$fIn copyright - single owner
000000481 650__ $$aFibrinogen$$019013
000000481 650__ $$aBlood Proteins$$015673
000000481 650__ $$aBlood Coagulation$$015652
000000481 650__ $$aCytokines$$028964
000000481 650__ $$aInterleukin-6$$028703
000000481 650__ $$aCardiovascular Diseases$$016152
000000481 691__ $$aSchool of Medicine$$041369
000000481 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000000481 7001_ $$aRein, Chantelle$$uOregon Health and Science University$$041354
000000481 7201_ $$aFarrell, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000481 8564_ $$9b2548bc2-3904-4aed-9569-a096a27be8b8$$s3016056$$uhttps://digitalcollections.ohsu.edu/record/481/files/482_etd.pdf$$ePublic$$2ba25e60096d82cf950f69e9c72071862$$31
000000481 905__ $$a/rest/prod/4f/16/c2/82/4f16c282r
000000481 909CO $$ooai:digitalcollections.ohsu.edu:481$$pstudent-work
000000481 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000481 980__ $$aTheses and Dissertations