000000483 001__ 483
000000483 005__ 20260304122104.0
000000483 0247_ $$2DOI$$a10.6083/M4FQ9TK2
000000483 037__ $$aETD
000000483 245__ $$aThe role of cyclophilin D in mitochondrial calcium homeostasis in adult neurons
000000483 260__ $$bOregon Health and Science University
000000483 269__ $$a2009
000000483 336__ $$aDissertation
000000483 502__ $$bPh.D.
000000483 520__ $$aMitochondrial dysfunction, particularly impaired calcium (Ca²⁺) regulation, is implicated in the pathology of many neurodegenerative diseases. To better understand the role of mitochondrial Ca²⁺ handling in neuronal vulnerability, this study compared mitochondrial Ca²⁺ dynamics in primary cortical neurons from adult cyclophilin D knockout (CyPD‑KO) and wild‑type (WT) mice. Neurons were transfected with a mitochondria‑targeted, ratiometric pericam Ca²⁺ indicator to measure mitochondrial Ca²⁺ responses in real time. These experiments provide insight into how the absence of cyclophilin D influences mitochondrial Ca²⁺ buffering and may clarify mechanisms linking mitochondrial dysfunction to neurodegeneration.
000000483 540__ $$fCC BY
000000483 542__ $$fIn copyright - single owner
000000483 650__ $$aHomeostasis$$020285
000000483 650__ $$aNerve Degeneration$$022797
000000483 650__ $$aCyclophilins$$032917
000000483 650__ $$aMitochondria$$022348
000000483 650__ $$aNeurons$$022858
000000483 650__ $$aMice$$036842
000000483 650__ $$aAging$$014358
000000483 650__ $$aNeurodegenerative Diseases$$031750
000000483 650__ $$aCognition$$016868
000000483 650__ $$aMitochondrial Diseases$$033486
000000483 691__ $$aSchool of Medicine$$041369
000000483 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000483 7001_ $$aBarsukova, Anna$$uOregon Health and Science University$$041354
000000483 7201_ $$aForte, Michael$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000483 8564_ $$9049649a3-8940-42c8-a3fc-3edda2ee146f$$s1665904$$uhttps://digitalcollections.ohsu.edu/record/483/files/484_etd.pdf$$ePublic$$2bc398ea6862c6c86b2ce7c1ac0f69551$$31
000000483 905__ $$a/rest/prod/tm/70/mv/16/tm70mv16z
000000483 909CO $$ooai:digitalcollections.ohsu.edu:483$$pstudent-work
000000483 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000483 980__ $$aTheses and Dissertations