000000005 001__ 5
000000005 005__ 20260423153036.0
000000005 0247_ $$2DOI$$a10.6083/M4BG2KW6
000000005 037__ $$aETD
000000005 245__ $$aX-ray absorption spectroscopy of copper: characterization of the human copper chaperone to superoxide dismutase
000000005 260__ $$bOregon Health and Science University
000000005 269__ $$a2006
000000005 336__ $$aDissertation
000000005 502__ $$bPh.D.
000000005 502__ $$gBiochemistry &amp; Molecular Biology (sunsetting)
000000005 520__ $$aThe human copper chaperone for superoxide dismutase (hCCS) is a multi-domain metalloprotein responsible for delivering copper to cytoplasmic superoxide dismutase (SOD). hCCS contains three putative copper-binding domains, but their functional roles were initially unclear. Structural and mutagenesis studies demonstrate that hCCS forms a binuclear copper–sulfur cluster through its C-terminal Domain III, which mediates dimerization and copper transfer to SOD. While Domain I is capable of binding copper and may contribute to regulatory functions, Domain III is essential for hCCS activity. These findings clarify the molecular mechanism of copper delivery to SOD and define the functional specialization of hCCS domains.
000000005 540__ $$fCC BY
000000005 542__ $$fIn copyright - single owner
000000005 650__ $$aCopper$$017086
000000005 650__ $$aSuperoxide Dismutase$$026628
000000005 650__ $$aX-Ray Absorption Spectroscopy$$038773
000000005 650__ $$aChemistry, Bioinorganic$$028376
000000005 691__ $$aOGI School of Science and Engineering$$041365
000000005 692__ $$aDepartment of Environmental and Biomolecular Systems$$041414
000000005 7001_ $$aStasser, Jay$$uOregon Health and Science University$$041354
000000005 7201_ $$aBlackburn, Ninian$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000005 8564_ $$9f7dd7e09-ee24-47e2-8327-25169ca23f58$$s13576791$$uhttps://digitalcollections.ohsu.edu/record/5/files/5_etd.pdf$$ePublic$$2343f5e90a6275a4458c903741dcde338$$31
000000005 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000005 905__ $$a/rest/prod/vm/40/xr/56/vm40xr56k
000000005 909CO $$ooai:digitalcollections.ohsu.edu:5$$pstudent-work
000000005 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000005 980__ $$aTheses and Dissertations