TY  - GEN
AB  - Advances in molecular and neural mechanisms of energy homeostasis have outpaced the behavioral tools needed to fully interpret their functional effects. Traditional measures of cumulative food intake fail to capture the complexity of ingestive behavior, underscoring the need for validated meal pattern analysis methods. This work develops and standardizes approaches for defining and analyzing meal patterns in mice, addressing long‑standing challenges in inter‑laboratory comparison. These tools are then applied to investigate how the central melanocortin system regulates feeding behavior. Analysis of neuronal POMC‑deficient mice reveals distinct meal pattern alterations underlying hyperphagia and examines their emergence during development. Together, this research links molecular mechanisms to detailed behavioral outcomes, improving the study of feeding regulation and energy balance.
AD  - Oregon Health and Science University
AU  - Richard, Christian
DA  - 2008
DO  - 10.6083/M4TT4NX1
DO  - DOI
ED  - Low, Malcolm
ED  - Mentor
ID  - 511
KW  - Mice
KW  - Melanocortins
KW  - Hyperphagia
KW  - Eating
KW  - Feeding Behavior
L1  - https://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf
N2  - Advances in molecular and neural mechanisms of energy homeostasis have outpaced the behavioral tools needed to fully interpret their functional effects. Traditional measures of cumulative food intake fail to capture the complexity of ingestive behavior, underscoring the need for validated meal pattern analysis methods. This work develops and standardizes approaches for defining and analyzing meal patterns in mice, addressing long‑standing challenges in inter‑laboratory comparison. These tools are then applied to investigate how the central melanocortin system regulates feeding behavior. Analysis of neuronal POMC‑deficient mice reveals distinct meal pattern alterations underlying hyperphagia and examines their emergence during development. Together, this research links molecular mechanisms to detailed behavioral outcomes, improving the study of feeding regulation and energy balance.
PB  - Oregon Health and Science University
PY  - 2008
T1  - Behavioral phenotyping meal patterns in mus musculus: validation, testing and application
TI  - Behavioral phenotyping meal patterns in mus musculus: validation, testing and application
UR  - https://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf
Y1  - 2008
ER  -