000000511 001__ 511
000000511 005__ 20260316100705.0
000000511 0247_ $$2DOI$$a10.6083/M4TT4NX1
000000511 037__ $$aETD
000000511 245__ $$aBehavioral phenotyping meal patterns in mus musculus: validation, testing and application
000000511 260__ $$bOregon Health and Science University
000000511 269__ $$a2008
000000511 336__ $$aDissertation
000000511 502__ $$bM.S.
000000511 502__ $$gBehavioral & Systems Neuroscience
000000511 520__ $$aAdvances in molecular and neural mechanisms of energy homeostasis have outpaced the behavioral tools needed to fully interpret their functional effects. Traditional measures of cumulative food intake fail to capture the complexity of ingestive behavior, underscoring the need for validated meal pattern analysis methods. This work develops and standardizes approaches for defining and analyzing meal patterns in mice, addressing long‑standing challenges in inter‑laboratory comparison. These tools are then applied to investigate how the central melanocortin system regulates feeding behavior. Analysis of neuronal POMC‑deficient mice reveals distinct meal pattern alterations underlying hyperphagia and examines their emergence during development. Together, this research links molecular mechanisms to detailed behavioral outcomes, improving the study of feeding regulation and energy balance.
000000511 540__ $$fCC BY
000000511 542__ $$fIn copyright - single owner
000000511 650__ $$aMice$$036842
000000511 650__ $$aMelanocortins$$037410
000000511 650__ $$aHyperphagia$$020528
000000511 650__ $$aEating$$018162
000000511 650__ $$aFeeding Behavior$$018929
000000511 691__ $$aSchool of Medicine$$041369
000000511 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000511 7001_ $$aRichard, Christian$$uOregon Health and Science University$$041354
000000511 7201_ $$aLow, Malcolm$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000511 8564_ $$9380a3521-cd92-4f40-9771-235327bd1b44$$s1212800$$uhttps://digitalcollections.ohsu.edu/record/511/files/512_etd.pdf$$ePublic$$25e76647af7bd9beabd014f1f562a90e6$$31
000000511 905__ $$a/rest/prod/qn/59/q4/02/qn59q402s
000000511 909CO $$ooai:digitalcollections.ohsu.edu:511$$pstudent-work
000000511 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000511 980__ $$aTheses and Dissertations