000000514 001__ 514
000000514 005__ 20260311144251.0
000000514 0247_ $$2DOI$$a10.6083/M4FN145P
000000514 037__ $$aETD
000000514 245__ $$aMaternal protein restriction in microswine: programming of postnatal growth, body composition and adipose tissue structure and function
000000514 260__ $$bOregon Health and Science University
000000514 269__ $$a2008
000000514 336__ $$aDissertation
000000514 502__ $$bPh.D.
000000514 520__ $$aAccelerated postnatal growth in low birth weight offspring is associated with increased risk of later cardiometabolic disease, but the relative roles of rapid growth versus obesity remain unclear. Using a microswine model, this study examined the effects of maternal protein restriction (MPR) during late gestation and early lactation on growth, adipose tissue development, metabolic function, and glucocorticoid signaling. Low‑protein offspring exhibited early growth restriction followed by accelerated juvenile growth, increased feed intake and efficiency, and rapid fat and lean mass accrual without obesity or adipocyte hypertrophy. Altered adiponectin expression occurred independently of HPA axis activation. Findings suggest that MPR programs both direct metabolic effects and indirect consequences mediated by accelerated growth, providing insight into mechanisms linking early nutrition to later disease risk.
000000514 540__ $$fCC BY
000000514 542__ $$fIn copyright - single owner
000000514 650__ $$aAdiponectin$$037141
000000514 650__ $$aSwine, Miniature$$026693
000000514 650__ $$aObesity$$023118
000000514 650__ $$aAdipose Tissue$$014265
000000514 650__ $$aPregnancy$$024523
000000514 650__ $$aDiet, Protein-Restricted$$031068
000000514 650__ $$aBody Composition$$015696
000000514 650__ $$aInfant, Low Birth Weight$$020781
000000514 650__ $$aMetabolic Syndrome$$033150
000000514 691__ $$aSchool of Medicine$$041369
000000514 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000514 7001_ $$aDuPriest, Elizabeth$$uOregon Health and Science University$$041354
000000514 7201_ $$aBagby, Susan$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000514 8564_ $$9db5ffa99-7b76-48cd-bc6c-daef2513301c$$s511916$$uhttps://digitalcollections.ohsu.edu/record/514/files/515_etd.pdf$$ePublic$$2a31d0e856ec9eb139a5b4df81fdb716b$$31
000000514 905__ $$a/rest/prod/gx/41/mh/87/gx41mh87z
000000514 909CO $$ooai:digitalcollections.ohsu.edu:514$$pstudent-work
000000514 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000514 980__ $$aTheses and Dissertations