TY  - THES
AB  - Optical micro‑angiography (OMAG) is a high‑resolution, label‑free imaging technique capable of resolving 3D blood perfusion at 10 μm within living microvascular beds. By separating static and moving light‑scattering components, OMAG provides detailed in vivo maps of microcirculatory flow without contrast agents. We applied OMAG to visualize cerebral microcirculation in adult mice through the intact skull and used it to assess cerebrovascular perfusion during and after induced stroke. Comparing mice treated with tissue plasminogen activator (tPA) or vehicle, OMAG revealed that tPA markedly improved reperfusion rate and blood volume in the affected hemisphere, correlating with better behavioral recovery and survival.
AD  - Oregon Health and Science University
AU  - Hurst, Sawan
DA  - 2010
DO  - 10.6083/M4XK8CHC
DO  - DOI
ED  - Wang, Ruikang
ED  - Advisor
ID  - 518
KW  - Infarction
KW  - Cerebral Angiography
KW  - Cerebral Arteries
KW  - Middle Cerebral Artery
KW  - Tissue Plasminogen Activator
KW  - Angiography
KW  - tpa
KW  - mcao
KW  - middle cerebral artery occlusion
KW  - omag
KW  - optical microangography
L1  - https://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf
N2  - Optical micro‑angiography (OMAG) is a high‑resolution, label‑free imaging technique capable of resolving 3D blood perfusion at 10 μm within living microvascular beds. By separating static and moving light‑scattering components, OMAG provides detailed in vivo maps of microcirculatory flow without contrast agents. We applied OMAG to visualize cerebral microcirculation in adult mice through the intact skull and used it to assess cerebrovascular perfusion during and after induced stroke. Comparing mice treated with tissue plasminogen activator (tPA) or vehicle, OMAG revealed that tPA markedly improved reperfusion rate and blood volume in the affected hemisphere, correlating with better behavioral recovery and survival.
PB  - Oregon Health and Science University
PY  - 2010
T1  - Effect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occlusion measured by optical micro-angiography
TI  - Effect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occlusion measured by optical micro-angiography
UR  - https://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf
Y1  - 2010
ER  -