000000518 001__ 518
000000518 005__ 20260217131639.0
000000518 0247_ $$2DOI$$a10.6083/M4XK8CHC
000000518 037__ $$aETD
000000518 245__ $$aEffect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occlusion measured by optical micro-angiography
000000518 260__ $$bOregon Health and Science University
000000518 269__ $$a2010
000000518 336__ $$aThesis
000000518 502__ $$bM.S.
000000518 520__ $$aOptical micro‑angiography (OMAG) is a high‑resolution, label‑free imaging technique capable of resolving 3D blood perfusion at 10 μm within living microvascular beds. By separating static and moving light‑scattering components, OMAG provides detailed in vivo maps of microcirculatory flow without contrast agents. We applied OMAG to visualize cerebral microcirculation in adult mice through the intact skull and used it to assess cerebrovascular perfusion during and after induced stroke. Comparing mice treated with tissue plasminogen activator (tPA) or vehicle, OMAG revealed that tPA markedly improved reperfusion rate and blood volume in the affected hemisphere, correlating with better behavioral recovery and survival.
000000518 540__ $$fCC BY
000000518 542__ $$fIn copyright - single owner
000000518 650__ $$aInfarction$$020789
000000518 650__ $$aCerebral Angiography$$016355
000000518 650__ $$aCerebral Arteries$$016358
000000518 650__ $$aMiddle Cerebral Artery$$032678
000000518 650__ $$aTissue Plasminogen Activator$$024249
000000518 650__ $$aAngiography$$014747
000000518 6531_ $$atpa
000000518 6531_ $$amcao
000000518 6531_ $$amiddle cerebral artery occlusion
000000518 6531_ $$aomag
000000518 6531_ $$aoptical microangography
000000518 691__ $$aSchool of Medicine$$041369
000000518 692__ $$aDepartment of Biomedical Engineering$$041397
000000518 7001_ $$aHurst, Sawan$$uOregon Health and Science University$$041354
000000518 7201_ $$aWang, Ruikang$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000518 8564_ $$9a432e3a1-7c32-4059-af42-daabafe9d82c$$s24740043$$uhttps://digitalcollections.ohsu.edu/record/518/files/519_etd.pdf$$ePublic$$2accb37198c44d491ef7ea5130431728d$$31
000000518 905__ $$a/rest/prod/gf/06/g2/66/gf06g2664
000000518 909CO $$ooai:digitalcollections.ohsu.edu:518$$pstudent-work
000000518 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000518 980__ $$aTheses and Dissertations