000000520 001__ 520
000000520 005__ 20260305173255.0
000000520 0247_ $$2DOI$$a10.6083/M4P26W33
000000520 037__ $$aETD
000000520 245__ $$aSignaling functions of Fanconi anemia proteins
000000520 260__ $$bOregon Health and Science University
000000520 269__ $$a2008
000000520 336__ $$aDissertation
000000520 502__ $$bPh.D.
000000520 520__ $$aFanconi anemia (FA) is characterized by bone marrow failure, yet its molecular basis remains unclear. This work identifies two non–DNA‑repair functions of FA proteins critical for hematopoietic cell survival. First, FANCC regulates Toll‑like receptor 8, and its loss drives excess TNF‑α production in FA cells. Second, FANCC, FANCG, and FANCD2 are required for proper STAT5 activation, involving inducible interactions that enable nuclear translocation of phosphorylated STAT5. Because STAT5 signaling is essential for hematopoietic stem cell survival, these defects likely contribute to marrow failure. These findings demonstrate multifunctional roles for FA proteins beyond the canonical nuclear core‑complex pathway.
000000520 540__ $$fCC BY
000000520 542__ $$fIn copyright - single owner
000000520 650__ $$aFanconi Anemia Complementation Group C Protein$$037135
000000520 650__ $$aFanconi Anemia Complementation Group D2 Protein$$037137
000000520 650__ $$aSTAT5 Transcription Factor$$036560
000000520 650__ $$aFanconi Anemia$$018886
000000520 650__ $$aChemistry$$016438
000000520 650__ $$aTumor Necrosis Factor-alpha$$027502
000000520 650__ $$aToll-Like Receptors$$036751
000000520 691__ $$aSchool of Medicine$$041369
000000520 692__ $$aDepartment of Biochemistry and Molecular Biology$$041396
000000520 7001_ $$aVanderwerf, Scott$$uOregon Health and Science University$$041354
000000520 8564_ $$908daf586-3458-4d25-9e3a-32777cd42052$$s5103084$$uhttps://digitalcollections.ohsu.edu/record/520/files/521_etd.pdf$$ePublic$$2ff33200997af8066d175297b10eda79c$$31
000000520 905__ $$a/rest/prod/nk/32/2d/33/nk322d33s
000000520 909CO $$ooai:digitalcollections.ohsu.edu:520$$pstudent-work
000000520 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000520 980__ $$aTheses and Dissertations