000000529 001__ 529
000000529 005__ 20260219142016.0
000000529 0247_ $$2DOI$$a10.6083/M4HD7SN9
000000529 037__ $$aETD
000000529 245__ $$aNetwork dynamics in olfactory cortical subregions
000000529 260__ $$bOregon Health and Science University
000000529 269__ $$a2010
000000529 336__ $$aDissertation
000000529 502__ $$bPh.D.
000000529 502__ $$gNeuroscience
000000529 520__ $$aPaleocortex, the olfactory cortex and evolutionary precursor of neocortex, remains comparatively understudied despite its relevance for understanding cortical processing. This dissertation establishes foundational physiological properties of paleocortex using whole‑cell patch‑clamp recordings in juvenile mouse brain slices. First, a slice preparation spanning several paleocortical subregions was developed to examine excitatory connectivity across regions. Next, the intrinsic and synaptic properties of anterior olfactory cortex (AOC) pyramidal neurons—previously uncharacterized with whole‑cell methods—were defined. Finally, expression patterns across eight transgenic and knock‑in mouse lines were evaluated to begin identifying paleocortical cell types. This work provides essential tools and baseline knowledge for future study of paleocortical structure and function.
000000529 540__ $$fCC BY
000000529 542__ $$fIn copyright - single owner
000000529 650__ $$aInterneurons$$020936
000000529 650__ $$aOlfactory Pathways$$023180
000000529 650__ $$aPiriform Cortex$$040787
000000529 650__ $$aPhylogeny$$024099
000000529 650__ $$aOlfactory Cortex$$040786
000000529 650__ $$aPyramidal Cells$$030387
000000529 6531_ $$aarea tempestas
000000529 6531_ $$aanterior olfactory nucleus
000000529 6531_ $$aendopiriform nucleus
000000529 6531_ $$apyramidal neurons
000000529 691__ $$aSchool of Medicine$$041369
000000529 692__ $$aVollum Institute$$041509
000000529 7001_ $$aMcGinley, Matthew$$uOregon Health and Science University$$041354
000000529 7201_ $$aWestbrook, Gary$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000529 8564_ $$9b2000c45-8808-4b84-93b5-daca287414a2$$s13593819$$uhttps://digitalcollections.ohsu.edu/record/529/files/530_etd.pdf$$ePublic$$26938b386543782f887cff0f57a377dbc$$31
000000529 905__ $$a/rest/prod/6t/05/3f/99/6t053f99d
000000529 909CO $$ooai:digitalcollections.ohsu.edu:529$$pstudent-work
000000529 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000529 980__ $$aTheses and Dissertations