TY  - GEN
AB  - This work examines the role of epoxyeicosatrienoic acids (EETs) in regulating cerebral blood flow through perivascular vasodilator nerves. Using molecular, cellular, and in vivo approaches, the studies demonstrate that parasympathetic and trigeminal neurons express active CYP‑2J epoxygenases capable of producing EETs. Although EETs release from primary trigeminal neurons was not detectable, endogenous EETs were shown to regulate neuropeptide secretion. In vivo nerve‑stimulation experiments further revealed that EETs contribute significantly to cerebral blood flow increases mediated by perivascular nerves. Overall, these findings identify EETs as key modulators of neurovascular signaling within the cerebral circulation.
AD  - Oregon Health and Science University
AU  - Iliff, Jeffrey
DA  - 2010
DO  - 10.6083/M4CN71WH
DO  - DOI
ED  - Alkayed, Nabil
ED  - Mentor
ID  - 530
KW  - Cerebrovascular Circulation
KW  - Vasodilation
KW  - Trigeminal Ganglion
KW  - Epoxide Hydrolases
L1  - https://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf
N2  - This work examines the role of epoxyeicosatrienoic acids (EETs) in regulating cerebral blood flow through perivascular vasodilator nerves. Using molecular, cellular, and in vivo approaches, the studies demonstrate that parasympathetic and trigeminal neurons express active CYP‑2J epoxygenases capable of producing EETs. Although EETs release from primary trigeminal neurons was not detectable, endogenous EETs were shown to regulate neuropeptide secretion. In vivo nerve‑stimulation experiments further revealed that EETs contribute significantly to cerebral blood flow increases mediated by perivascular nerves. Overall, these findings identify EETs as key modulators of neurovascular signaling within the cerebral circulation.
PB  - Oregon Health and Science University
PY  - 2010
T1  - The role of P450 epoxyeicosanoids in cerebral extrinsic perivascular vasodilator nerve function
TI  - The role of P450 epoxyeicosanoids in cerebral extrinsic perivascular vasodilator nerve function
UR  - https://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf
Y1  - 2010
ER  -