000000530 001__ 530
000000530 005__ 20260226131528.0
000000530 0247_ $$2DOI$$a10.6083/M4CN71WH
000000530 037__ $$aETD
000000530 245__ $$aThe role of P450 epoxyeicosanoids in cerebral extrinsic perivascular vasodilator nerve function
000000530 260__ $$bOregon Health and Science University
000000530 269__ $$a2010
000000530 336__ $$aDissertation
000000530 502__ $$bPh.D.
000000530 520__ $$aThis work examines the role of epoxyeicosatrienoic acids (EETs) in regulating cerebral blood flow through perivascular vasodilator nerves. Using molecular, cellular, and in vivo approaches, the studies demonstrate that parasympathetic and trigeminal neurons express active CYP‑2J epoxygenases capable of producing EETs. Although EETs release from primary trigeminal neurons was not detectable, endogenous EETs were shown to regulate neuropeptide secretion. In vivo nerve‑stimulation experiments further revealed that EETs contribute significantly to cerebral blood flow increases mediated by perivascular nerves. Overall, these findings identify EETs as key modulators of neurovascular signaling within the cerebral circulation.
000000530 540__ $$fCC BY
000000530 542__ $$fIn copyright - single owner
000000530 650__ $$aCerebrovascular Circulation$$016382
000000530 650__ $$aVasodilation$$027743
000000530 650__ $$aTrigeminal Ganglion$$025860
000000530 650__ $$aEpoxide Hydrolases$$018554
000000530 691__ $$aSchool of Medicine$$041369
000000530 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000530 7001_ $$aIliff, Jeffrey$$uOregon Health and Science University$$041354
000000530 7201_ $$aAlkayed, Nabil$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000530 8564_ $$9cd89a34b-51da-4d2e-a71b-e2c043b865ef$$s2381618$$uhttps://digitalcollections.ohsu.edu/record/530/files/531_etd.pdf$$ePublic$$24916053bf8689519ca669a566823ee2e$$31
000000530 905__ $$a/rest/prod/51/38/jd/88/5138jd881
000000530 909CO $$ooai:digitalcollections.ohsu.edu:530$$pstudent-work
000000530 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000530 980__ $$aTheses and Dissertations