000000532 001__ 532
000000532 005__ 20260203133607.0
000000532 0247_ $$2DOI$$a10.6083/M4445JFS
000000532 037__ $$aETD
000000532 245__ $$aAntiviral properties of BST-2 and Kaposi's sarcoma-associated herpesvirus countermeasures
000000532 260__ $$bOregon Health and Science University
000000532 269__ $$a2010
000000532 336__ $$aThesis
000000532 502__ $$bM.S.
000000532 520__ $$aKaposi’s sarcoma–associated herpesvirus (KSHV) uses immune‑evasion strategies to support successful infection, including the activity of its viral E3 ubiquitin ligase, K5. While K5 is known to downregulate MHC class I, this study shows that it also targets the antiviral factor BST‑2, which restricts release of enveloped viruses by tethering virions to the cell surface. We demonstrate that K5 ubiquitinates lysines on the cytoplasmic tail of BST‑2 after it exits the ER, directing it to lysosomal degradation. In the absence of K5, BST‑2 restricts KSHV egress. These findings identify BST‑2 as a bona fide K5 substrate and highlight K5’s role in countering innate antiviral defenses.
000000532 540__ $$fCC BY
000000532 542__ $$fIn copyright - single owner
000000532 650__ $$aVirus Release$$038820
000000532 650__ $$aMembrane Glycoproteins$$022006
000000532 650__ $$aImmune Evasion$$038852
000000532 650__ $$aHerpesvirus 8, Human$$031505
000000532 650__ $$aImmunity, Innate$$020672
000000532 6531_ $$aviral egress
000000532 6531_ $$aherpesvirus diseases
000000532 691__ $$aSchool of Medicine$$041369
000000532 692__ $$aDepartment of Science and Engineering$$041447
000000532 7001_ $$aHines, Jennie$$uOregon Health and Science University$$041354
000000532 7201_ $$aFruch, Klaus$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000532 8564_ $$9236aa118-f1ef-4f66-aa2e-1b20de093e59$$s779889$$uhttps://digitalcollections.ohsu.edu/record/532/files/533_etd.pdf$$ePublic$$2de16090ce21297c4c8c7bdfd99312bfb$$31
000000532 905__ $$a/rest/prod/jh/34/3s/30/jh343s30f
000000532 909CO $$ooai:digitalcollections.ohsu.edu:532$$pstudent-work
000000532 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000532 980__ $$aTheses and Dissertations