TY  - GEN
AB  - Retinal ganglion cells (RGCs) encode key visual features, yet the synaptic mechanisms shaping their responses remain incompletely understood. This study examines light‑evoked inputs to OFF brisk‑sustained (OFF‑BS) RGCs in rabbit retina, focusing on the contributions of NMDA, AMPA, and inhibitory pathways. We show that NMDA and AMPA receptors provide distinct excitatory synaptic inputs, differing in contrast adaptation and sensitivity to GABAergic blockade. NMDA receptors preferentially enhance responses at low contrasts, while AMPA inputs dominate at higher contrasts. Additionally, a glycinergic disinhibitory input from the ON pathway boosts contrast sensitivity at high temporal frequencies. Together, these findings identify two synaptic circuits that fine‑tune contrast and temporal processing in OFF‑BS RGCs.
AD  - Oregon Health and Science University
AU  - Buldyrev, Ilya
DA  - 2010
DO  - 10.6083/M4QZ27XR
DO  - DOI
ED  - Taylor, W. Rowland
ED  - Advisor
ID  - 535
KW  - Amacrine Cells
KW  - Neural Inhibition
KW  - Synaptic Transmission
KW  - Retinal Ganglion Cells
KW  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
KW  - Receptors, N-Methyl-D-Aspartate
KW  - N-Methylaspartate
KW  - Action Potentials
KW  - Rabbits
L1  - https://digitalcollections.ohsu.edu/record/535/files/536_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/535/files/536_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/535/files/536_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/535/files/536_etd.pdf
N2  - Retinal ganglion cells (RGCs) encode key visual features, yet the synaptic mechanisms shaping their responses remain incompletely understood. This study examines light‑evoked inputs to OFF brisk‑sustained (OFF‑BS) RGCs in rabbit retina, focusing on the contributions of NMDA, AMPA, and inhibitory pathways. We show that NMDA and AMPA receptors provide distinct excitatory synaptic inputs, differing in contrast adaptation and sensitivity to GABAergic blockade. NMDA receptors preferentially enhance responses at low contrasts, while AMPA inputs dominate at higher contrasts. Additionally, a glycinergic disinhibitory input from the ON pathway boosts contrast sensitivity at high temporal frequencies. Together, these findings identify two synaptic circuits that fine‑tune contrast and temporal processing in OFF‑BS RGCs.
PB  - Oregon Health and Science University
PY  - 2010
T1  - The role of inner retinal inhibitory circuits in tuning off retinal ganglion cell output
TI  - The role of inner retinal inhibitory circuits in tuning off retinal ganglion cell output
UR  - https://digitalcollections.ohsu.edu/record/535/files/536_etd.pdf
Y1  - 2010
ER  -